**South San Francisco, CA – November 15, 2021** – PACT Pharma, Inc., a clinical-stage company developing transformational personalized neoTCR-T cell therapies for the eradication of solid tumors, today announced that new data related to its PACTImmune™ Database were presented at the Society for Immunotherapy of Cancer’s (SITC) 36th Annual Meeting. The results were featured in a poster presentation (#820) entitled, “Machine learning significantly improves neoantigen-HLA predictions utilizing > 26,000 data points from the PACTImmune Database,” at the SITC conference, which was held November 10-14, 2021. 

The presented results reported findings from a study in which PACT applied machine learning to more than 26,000 manufactured polypeptides consisting of the initially predicted neoE peptide together with Beta-2-Microglobulin and the HLA heavy chain for 62 different HLA alleles. Data demonstrated that PACT’s approach significantly improved neoE-HLA predictions, resulting in a 22% improvement in success rates on prospective data as compared to the widely used netMHCpan4.1 predictions. Additionally, the presentation outlined key elements of PACT’s strategy for continued enhancements to its approach to further improve its predictive power. 

“The PACTImmune Database enables us to tune and continue to learn from our platform and its growing data assets. Based on retrospective analysis we know that higher predicted neoE-HLA success corelates with more TCRs captured per patient. Ultimately, these improved predictions should give us more actionable neoTCR options for patients in our clinical trial,” said Eric Stawiski, Vice President of Bioinformatics at PACT and presenter of the SITC poster.

The abstract related to this presentation is available on the SITC website and can be accessed at: [https://jitc.bmj.com/content/9/Suppl_2/A858](https://jitc.bmj.com/content/9/Suppl_2/A858).

**About PACTImmune™ Database**
PACT has developed a proprietary approach to validate predicted neoepitopes (neoEs) and their cognate T cell receptors (neoTCRs) by capturing neoepitope-specific T cells from peripheral blood. This neoTCR discovery and validation process is being applied in a clinical trial (NCT03970382) evaluating personalized neoTCR-T cell therapy to treat patients across eight solid tumor types. Extensive pre-, on- and post-treatment data related to this trial has been accumulated in the PACTImmune Database (PIDB) which represents a growing data asset for patient-specific tumor immunogenicity in solid tumors.

**About PACT Pharma, Inc.**
PACT is a clinical-stage biopharmaceutical company pioneering individualized, non-viral precision genome engineered, tumor-specific T cell therapies for the treatment of patients with solid cancers. PACT is now enrolling patients in its first-in-human Phase 1 clinical trial.

Each person's cancer emerges with a private signature of mutations. PACT identifies these cancer mutation targets (neoantigens) for each person, biochemically verifies and captures T cells from their blood and uses its proprietary, cutting edge (non-viral) precision genome engineering technologies to manufacture a personalized immune cell therapy product for each person with cancer.

For more information, please visit [www.pactpharma.com](https://www.pactpharma.com).

Contacts:

**PACT Pharma**
Atulya Agarwal 
atulya@pactpharma.com

**Vida Strategic Partners (on behalf of PACT Pharma)**
Tim Brons (Media)
415-675-7402
tbrons@vidasp.com


PACT Reports New Data Highlighting Predictive Power of Machine Learning Approach Leveraging PACTImmune™ Database at Society for Immunotherapy of Cancer’s (SITC) 36th Annual Meeting

**South San Francisco – January 11, 2021** – PACT Pharma, Inc., a clinical-stage company developing transformational personalized neoTCR-T cell therapies for the eradication of solid tumors, today announced that the company will present at the 39th Annual J.P. Morgan Healthcare Conference, which is being held virtually, on January 11, 2021 at 7:30 a.m. PT/10:30 a.m. ET.  

**About PACT Pharma**

PACT is a clinical-stage biopharmaceutical company pioneering individualized, non-viral precision genome engineered, tumor-specific T cell therapies for the treatment of patients with solid cancers. PACT is now enrolling patients in its first-in-human Phase 1 clinical trial. 

Each person's cancer emerges with a private signature of mutations. PACT identifies these cancer mutation targets (neoantigens) for each person, biochemically verifies and captures T cells from their blood and uses its proprietary, cutting edge (non-viral) precision genome engineering technologies to manufacture a personalized immune cell therapy product for each person with cancer.

For more information please visit[ www.pactpharma.com]( www.pactpharma.com). 


**Media Contact**

Sarah Sutton
Finsbury Glover Hering (FGH)
[ssutton@fgh.com](mailto:ssutton@fgh.com) 
202-337-0808

**Investor Contact**

Uneek Mehra
[umehra@pactpharma.com](mailto:umehra@pactpharma.com)


PACT Pharma to Present at the 39th Annual J.P. Morgan Healthcare Conference

Press Releases

- The round was led by Vida Ventures, a next generation life science venture firm with industry-leading experience in cell and gene therapy  
- The financing will be used to expand clinical & manufacturing development to deliver clinical data for patients with multiple solid tumor types  

SOUTH SAN FRANCISCO, Calif., Jan. 10, 2020 /PRNewswire/ — PACT Pharma, in pursuit of its vision to eradicate solid tumors using transformational, first-in-class fully personalized NeoTCR-T cell therapies, today announced that it has closed an oversubscribed $75 million Series C financing. This round, led by Vida Ventures, a next generation life science venture firm with industry-leading experience in the cell and gene therapy, also included current investors of PACT.  

Combined with proceeds from previous financings, PACT will use the Series C proceeds to expand the scope of its clinical plan to investigate NeoTCR-T cell products targeting multiple neoantigens for a spectrum of solid tumor types. In addition to clinical expansion, PACT will open in 2020 a next-gen GMP manufacturing facility in South San Francisco to support the end-to-end production and supply chain for the engineering of personalized neoantigen-targeted autologous T cells. Under the direction of industry veteran Tim Moore, President and Chief Technology Officer, PACT will leverage the new in-house manufacturing facility to automate manufacturing and analytic processes to reduce cycle time and manufacturing costs.  

“PACT has grown from company launch to opening its first-in-kind clinical trial in two years. Our progress has been exhilarating and the support from our existing investors has made that progress possible,” said Alex Franzusoff, PhD, Chief Executive Officer of PACT Pharma. “As we look to the next stage of our development and expansion of our clinical programs, we are excited to have interest from a new group of prominent investors who both understand the potential of NeoTCR-T cell therapy and have direct experience in the space. Vida Ventures stood out as a partner of choice, given their depth of operational experience in research, clinical development and manufacturing in cell therapy as well as their proven ability to guide companies like Kite and Allogene across key stages of development.  

As part of the Series C financing, Helen S. Kim, Managing Director at Vida Ventures, will join the Company’s Board of Directors. Ms. Kim brings over 25 years of biotechnology leadership experience and serves on the boards of Assembly Biosciences, Applied Molecular Transport, A2 Biotherapeutics and Exicure, Inc.  

“Our investment in PACT Pharma represents our goal to fund scientific advances by embracing cutting edge innovation with the potential to make a meaningful difference in the lives of patients,” said Kim. “PACT has developed a pioneering platform of personalized designer T cells with the potential to target some of the most elusive solid cancers facing society today.”  

**ABOUT PACT Pharma**  

PACT Pharma is an independent, privately funded clinical stage company, based in South San Francisco, California, developing transformational personalized neoTCR-T cell therapies for the eradication of solid tumors and is now enrolling patients in its first-in-human Phase 1 clinical studies at several key academic centers of the CIRM-funded Alpha Clinic network, in California.  

PACT Pharma’s distinguised co-founders, David Baltimore (Nobel Laureate), Antoni Ribas, Jim Heath, Terry Rosen and Juan Jaen launched the company in early 2017. The company is backed by GV (formerly Google Ventures), Canaan, Casdin Capital, Droia, Foresite Capital, Invus Opportunities, Pontifax and Wu Capital and is supported by investment from AbbVie Ventures and Taiho Ventures. PACT Pharma’s technology is designed to individually program tumor-exclusive targeting into each patient’s own immune system cells to eradicate their own cancer. The process, which is currently in Phase 1 clinical testing, involves taking a biopsy of a person’s cancer tissue to assess the tumor-exclusive mutations with predictive algorithms, then to biologically verify the optimal targets by capturing T cells from blood that already recognize the mutations. Using the T cell receptor information from the captured T cells, together with proprietary, cutting edge, (non-viral) precision genome engineering technologies, fresh patient T cells are edited in one step to craft tumor-specific neoTCR-P1 cells. These private designer T cells have been shown to immediately kill mutation-expressing tumors in pre-clinical studies, and to create a deep reservoir of ‘ready-to-go’ neoTCR-P1 cells with the potential for long term persistence to prevent future cancer recurrence. These developments offer PACT exceptional prospects to leverage the potential of ideal tumor targets and biologically verified neoTCRs into clinical development of neoTCR-T adoptive cell therapies.  

**CONTACT:** William Nevius, wnevius(at)canaan.com

PACT Pharma Raises $75M in Oversubscribed Series C Financing to Develop Fully Personalized NeoTCR-T Cell Therapies for Patients with Cancer

PACT is a company pushing the frontiers of science, technology and medicine. We are creating T cell therapies to alter the course of cancer and meaningfully impact the lives of patients who urgently need breakthrough therapies. We are building a team of driven, talented and passionate individuals committed to bringing these novel personalized therapies to people living with cancer.

Join Us

PACT is a clinical stage immuno-oncology company dedicated to engineering T cell therapies by seeking to harness the inherent biology and curative potential of each patient's immune system to treat their cancer and advance the field of immune-driven medicines.

Who We Are

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor.  If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer! We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for a QC Associate II or III level for the QC Microbiology group, reporting to the Senior Manager of QC Microbiology and continue advancing PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your contributions to PACT Pharma’s personalized process rapidly translate into the clinic and impact patient lives. What You Will Do: <ul><li> Collect environmental, personnel, and utility samples of cleanroom manufacturing facilities following written sampling plans</li><li> Perform clinical product in-process and lot release testing</li><li> Assess new rapid microbiology methods and analytical technology for suitability to support the manufacture and assess the quality of cell therapy products.</li><li> Lead and perform microbiological method transfer and validation (e.g. rapid sterility, endotoxin, mycoplasma)</li><li> Design and support qualification of cleanroom facilities and clean utilities</li><li> Review data obtained for compliance to specifications and reports abnormalities and applies critical thought to solving problems of complex scope</li><li> Lead laboratory investigations and support deviation investigations for cGMP clinical manufacturing and supporting QC equipment</li><li> Be a liaison (SME) across functions to ensure adherence to microbial contamination control strategies and ensure product quality</li><li> General QC Microbiology lab support including housekeeping, equipment maintenance, and supplies inventory; knowledge of Laboratory 5S principles, preferred.</li><li> Candidate must apply knowledge of cGMP/GLP, and adhere to company safety procedures and guidelines </li><li> Document sampling and testing in accordance with Good Documentation Practices </li></ul>Qualifications:<ul><li> Bachelor’s degree in relevant biological sciences (Microbiology degree preferred)</li><li> Minimum of 3 years of experience of QC related experience in the Pharmaceutical and/or biologics industry</li><li> Pharmaceutical microbiology knowledge and hands-on experiences in quality control testing, such as surface and air monitoring, bioburden testing, endotoxin testing, sterility testing, growth promotion, and Gram stain</li><li> Prior experience in environmental monitoring and quality control microbiology laboratory testing for a GMP manufacturing facility</li><li> Strong analytical and problem-solving skills</li><li> Proficient aseptic technique and preferred experience in gowning procedures</li><li> Well organized and able to shift priorities effectively</li><li> Good communication skills both verbally and written</li><li> Ability to work independently as well as within a team, demonstrate initiative and accountability, and strong attention to detail</li><li> The candidate should enjoy operating in an exceptionally dynamic and cooperative environment</li><li> They must be able to communicate clearly and concisely, both verbally and in the form of written reports, laboratory notebooks, and batch records.</li></ul> PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Corporate (South San Francisco)

QC Associate II / III - Microbiology

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment and working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer! We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Bioprocess Manufacturing Associate II  who will continue advancing PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your contributions to PACT Pharma’s personalized process rapidly translate into the clinic and impact patient lives.What You Will Do: <ul><li> Perform cGMP processing and documentation required to produce and assess safe and efficacious products within an ISO cleanroom environment using aseptic techniques as applicable</li><li> Under the supervision of the Supervisor/Manager, assist in the implementation of production and large-scale manufacturing procedures to optimize processes and documentation, such as standard operating procedures, batch records, etc.</li><li> Contribute to cross-functional discussions with Process Development (PD) and Manufacturing Sciences and Technology (MSAT), to investigate technical issues, as well as improve the efficiency of the process</li><li> Exercise a continuous improvement mindset to enable the creation or enhancement of Manufacturing tools, processes, documents, etc.</li><li style="text-align: justify;line-height: normal;"> Support the investigation and/or execution of quality records (deviations, change controls, corrective and preventative actions) for timely closure</li></ul>Qualifications:<ul><li style="line-height: 107.0%;"> Bachelor’s degree or associate degree in a biologics, biotechnology, engineering, or related field preferred</li><li style="line-height: 107.0%;"> A minimum of 4 years of applicable experience in cGMP manufacturing</li><li style="line-height: 107.0%;"> Aseptic/cell processing and clean room experience are strongly preferred</li><li style="line-height: 107.0%;"> Experience in cell counting and cell selection operation preferred </li><li style="line-height: 107.0%;"> Strong work ethic, methodical approach to new challenges</li><li style="line-height: 107.0%;"> Must be able to work as a team, as well as independently with minimal supervision</li><li style="line-height: 107.0%;"> Demonstrates tact and courtesy in dealing with others</li><li style="line-height: 107.0%;"> Excellent organizational skills and attention to detail</li><li style="line-height: 107.0%;"> Good verbal and written communication skills</li><li style="line-height: 107.0%;"> Skills in Microsoft Office (Excel, Word) preferred</li><li style="line-height: 107.0%;"> Able to adapt to company growth and evolving responsibilities</li><li style="line-height: 107.0%;"> Ability to work a flexible schedule that may include nights, weekends, and/or holidays </li></ul>Physical Demands:The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of the job. While performing the duties of this job, the employee is frequently required to stand; walk; sit; bend; stretch; use hands to finger, handle or feel; reach with hands and arms, and talk or hear. The employee is regularly required to climb or balance; stoop, kneel, or crouch. The employee is frequently required to lift and/or move up to 30 pounds. Non-absorbent laboratory coats are required, as well as latex (or a non-latex substitute) gloves. When working with potentially hazardous materials that may spray, aerosol, or otherwise contact skin or mucous membranes, face shields or goggles must be worn. Heavy cryo gloves must be used when working with liquid nitrogen.  PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Bioprocess Manufacturing Associate II

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor.  If you desire a stimulating fast-paced environment and working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer!  We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Bioprocess Manufacturing Specialist who will continue advancing PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your contributions to PACT Pharma’s personalized process rapidly translate into the clinic and impact patient lives.What You Will Do:  <ul><li style="line-height: normal;"> Perform cGMP processing and documentation required to produce and assess safe and efficacious products within an ISO cleanroom environment using aseptic techniques as applicable</li><li style="line-height: normal;"> Develop, update, and implement production and large-scale manufacturing procedures to optimize processes and regulatory requirements, such as standard operating procedures, batch records, etc.</li><li style="line-height: normal;"> Resolve or partner with cross-functional teams, such as Process Development (PD) and Manufacturing Sciences and Technology (MSAT), to scale up and investigate technical issues, as well as maintenance of production equipment</li><li style="line-height: normal;"> Contribute to and/or own quality records (deviation, change controls, corrective and preventative actions) and complete in a timely manner</li><li style="line-height: normal;"> Provide justification and review existing operational and process discrepancies and provide technical expertise to improve procedures</li><li style="line-height: normal;"> Exercise a continuous improvement mindset to create or enhance Manufacturing tools, processes, documents, etc.</li><li style="line-height: normal;"> Provide manufacturing expertise for studies related to equipment and process performance, comparability, and reliability</li><li style="line-height: normal;"> Contribute to operating equipment specifications and improve manufacturing techniques</li><li style="line-height: normal;"> Evaluate, select and order equipment that is most appropriate and cost-effective for the manufacture of company products</li></ul>Qualifications:<ul><li style="line-height: normal;"> Bachelor’s degree in a biologics, biotechnology, engineering, or related field with 5+ years of manufacturing or applicable experience in a cGMP environment</li><li style="line-height: normal;"> Aseptic/cell processing and clean room experience required</li><li style="line-height: normal;"> Ability to communicate clearly and concisely, both verbally and in the form of written reports</li><li style="line-height: normal;"> Effective in solving and communicating manufacturing-related issues to relevant stakeholders</li><li style="line-height: normal;"> Demonstrated ability on filling the gaps between business requirements and suggesting reasonable alternatives when necessary</li><li style="line-height: normal;"> Ability to build partnerships with cross-functional teams without formal authority</li><li style="line-height: normal;"> Effective organizational skills, time management, and ability to coordinate workload and meet established deadlines</li><li style="line-height: normal;"> Flexible and able to adapt to company growth and evolving responsibilities</li><li style="line-height: normal;"> Ability to work a flexible schedule that may include nights, weekends, and/or holidays</li><li style="line-height: normal;"> GLP and GMP experience a plus </li></ul>Physical Demands:The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of the job. While performing the duties of this job, the employee is frequently required to stand; walk; sit; bend; stretch; use hands to finger, handle or feel; reach with hands and arms, and talk or hear. The employee is regularly required to climb or balance; stoop, kneel, or crouch. The employee is frequently required to lift and/or move up to 30 pounds. Non-absorbent gowning or laboratory coats are required, as well as latex (or a non-latex substitute) gloves. When working with potentially hazardous materials that may spray, aerosol, or otherwise contact skin or mucous membranes, face shields or goggles must be worn. Heavy cryo gloves must be used when working with liquid nitrogen.  PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Bioprocess Manufacturing Specialist

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor.  If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer! We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for a QC Associate III / Senior Associate for the QC Microbiology group, reporting to the Senior Manager of QC Microbiology and continue advancing PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your contributions to PACT Pharma’s personalized process rapidly translate into the clinic and impact patient lives. What You Will Do: <ul><li> Collect environmental, personnel, and utility samples of cleanroom manufacturing facilities following written sampling plans</li><li> Perform clinical product in-process and lot release testing</li><li> Assess new rapid microbiology methods and analytical technology for suitability to support the manufacture and assess the quality of cell therapy products.</li><li> Lead and perform microbiological method transfer and validation (e.g. rapid sterility, endotoxin, mycoplasma)</li><li> Design and support qualification of cleanroom facilities and clean utilities</li><li> Review data obtained for compliance to specifications and reports abnormalities and applies critical thought to solving problems of complex scope</li><li> Lead laboratory investigations and support deviation investigations for cGMP clinical manufacturing and supporting QC equipment</li><li> Be a liaison (SME) across functions to ensure adherence to microbial contamination control strategies and ensure product quality</li><li> General QC Microbiology lab support including housekeeping, equipment maintenance, and supplies inventory; knowledge of Laboratory 5S principles, preferred.</li><li> Candidate must apply knowledge of cGMP/GLP, and adhere to company safety procedures and guidelines </li><li> Document sampling and testing in accordance with Good Documentation Practices </li></ul>Qualifications:<ul><li> Bachelor’s degree in relevant biological sciences (Microbiology degree preferred)</li><li> Minimum of 8 years of experience of QC related experience in the Pharmaceutical and/or biologics industry</li><li> Pharmaceutical microbiology knowledge and hands-on experiences in quality control testing, such as surface and air monitoring, bioburden testing, endotoxin testing, sterility testing, growth promotion, and Gram stain</li><li> Prior experience in environmental monitoring and quality control microbiology laboratory testing for a GMP manufacturing facility</li><li> Strong analytical and problem-solving skills</li><li> Proficient aseptic technique and preferred experience in gowning procedures</li><li> Well organized and able to shift priorities effectively</li><li> Good communication skills both verbally and written</li><li> Ability to work independently as well as within a team, demonstrate initiative and accountability, and strong attention to detail</li><li> The candidate should enjoy operating in an exceptionally dynamic and cooperative environment</li><li> They must be able to communicate clearly and concisely, both verbally and in the form of written reports, laboratory notebooks, and batch records.</li></ul> PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Sr. QC Associate Microbiology

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! We are in the San Francisco bay area, the heart of the world’s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for a Senior Research Associate in the clinical pipeline group to continue advancing PACT’s cutting-edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.The person in this role will be responsible for evaluation of T cells as part of the product selection process prior to the manufacturing of PACT's adoptive cell therapy product (neoTCR-P1) for clinical patients. This process is performed in a GMP-like laboratory setting and includes characterizing T cell phenotype and functionality using state-of-the-art flow cytometry-based methods and automation. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.Responsibilities:<ul><li style="line-height: normal;"> The ideal candidate will perform and thoroughly document ex vivo T cell functional assays according to established procedures</li><li style="line-height: normal;"> Demonstrate strong accountability, organizational, and interpersonal skills; will collaborate and work effectively within the team and across multi-functional teams</li><li style="line-height: normal;"> Identify areas of the process for improvement and work with the process development team to test and implement improvements</li><li style="line-height: normal;"> Analyze flow cytometry data and carefully write reports that will help inform product candidate selection in clinical patients </li><li style="line-height: normal;"> Operate advanced liquid handling and robotic laboratory automation</li><li> Become a process expert and mentor/train research associates in performing the workflows</li><li> Assist junior team members with issues that may arise, including any necessary documentation </li></ul>Qualifications: <ul><li style="line-height: normal;background: white;"> Bachelor’s degree with 4+ or Master’s with 2+ years of industry experience, preferably in a production environment</li><li> The candidate should be proficient in state-of-the-art techniques for characterizing T cell phenotype and measuring T cell functionality (antigen-specific killing assays, cytokine production, proliferation)</li><li> The candidate should be proficient at cell-based bioassays, ELISA, flow cytometry, primary human T cells, and/or mammalian cell culture</li><li style="line-height: normal;background: white;"> Must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports</li><li style="line-height: normal;background: white;"> Demonstrated ability to work well within a team environment is a must</li><li> Experience with automated lab workflows and liquid handlers is a plus</li><li style="line-height: normal;background: white;"> Experience operating within a formal quality management system. cGMP or ISO 13485 production experience is a plus </li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Senior Research Associate - Tumor Immunology

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor.  If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer!We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently seeking a Senior Intellectual Property Counsel who will report to our Chief Legal & Business Strategy Officer and who will lead the company’s intellectual property strategy.  The position will require working closely with PACT Pharma’s research, development, manufacturing, and clinical teams on intellectual property and contract matters.  The individual should be able to independently identify and manage intellectual property and other legal issues potentially impacting the business and provide a legal strategy to promote the success of the company.  The individual will work on cross-functional teams and will collaborate with people throughout the company, including the senior management and executive teams.  What You Will Do:<ul><li> Develop and implement IP strategy, as well as policies and procedures to ensure the protection of the company’s intellectual property. </li><li> Work closely with research and development personnel to identify patentable inventions, participate in invention disclosure assessments and provide guidance regarding the patentability of inventions under review.</li><li> Develop and manage strategic patent portfolios including drafting and prosecuting patent applications worldwide in a diverse and growing technological field to create an intellectual property portfolio aligned with the strategy of the company.</li><li> Conduct due diligence (including freedom-to-operate, infringement, and validity analyses).</li><li> Monitor and analyze the competitive intellectual property and advise senior management and the executive team on the implications of such rights. </li><li> Educate internal personnel on relevant IP laws and related business issues.</li><li> Manage all trademarks.</li><li> Draft and review contracts and advise on various transactional matters (e.g. non-disclosure agreements, materials transfer agreements, licensing agreements, and collaborations).</li><li> Effectively manage external relationships with outside counsel and collaborators.</li></ul>Qualifications:<ul><li style="line-height: 15.0pt;background: white;">J.D. degree and admission before a State bar or fully qualified legal credentials in California </li><li style="line-height: 15.0pt;background: white;">Relevant life sciences degree, preferably a PhD </li><li style="line-height: 15.0pt;background: white;">At least 6 years of intellectual property experience in the life sciences industry as in-house patent counsel and/or in a nationally recognized law firm with at least 3 years of drafting and negotiating contracts</li><li style="line-height: 15.0pt;background: white;">Significant patent drafting and prosecution experience required</li><li style="line-height: 15.0pt;background: white;">Registered as an attorney before the USPTO </li><li style="line-height: 15.0pt;background: white;">Strong patent database searching skills are desirable</li><li style="line-height: 15.0pt;background: white;">Significant agreement and transactional experience required</li><li style="line-height: 15.0pt;background: white;">Ability to work well with all levels of management and staff</li><li style="color: rgb(45,45,45);line-height: normal;">Ability to work in a fast-paced, start-up environment</li><li style="color: rgb(45,45,45);line-height: normal;">Excellent problem-solving skills and ability to work with others to resolve conflict in order to meet objectives</li><li style="color: rgb(45,45,45);line-height: normal;">Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously while remaining flexible and prioritizing responsibilities</li><li style="color: rgb(45,45,45);line-height: normal;">Excellent organizational skills and an ability to prioritize effectively to deliver results within reasonably established timelines</li><li style="color: rgb(45,45,45);line-height: normal;">Ability to work independently and as part of a team</li><li style="color: rgb(45,45,45);line-height: normal;">Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment</li><li style="color: rgb(45,45,45);line-height: normal;">Candidates must be authorized to work in the U.S. </li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Senior Intellectual Property Counsel

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer! We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Senior Bioinformatics Software Engineering who will report to the Director of Software Engineering and continue advancing PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your contributions to PACT Pharma’s personalized process rapidly translate into the clinic and impact patient lives.What You Will Do: Great software engineering is vital to a better understanding of biology and winning the war against cancer. At PACT Pharma, we are operating in high gear collecting biological and medical data that will transform our understanding of cancer and will let us develop a better treatment against this disease. In this role, you will be responsible for tools and algorithms that help researchers with the analysis of genomic, transcriptomic, and proteomic data. You will work with computational biologists and software engineers to develop and improve the next generation of genomic data infrastructure, which can help us keep pace with the continuously growing number of patients we treat. You will lead the development of scalable data processing systems and scientific databases. PACT Pharma is looking for an exceptional Senior Bioinformatics Software Engineer to join our software engineering group and be a part of the team making this transformation real.<ul><li style="color: rgb(45,45,45);line-height: normal;">Participate in requirements and design review meetings to create comprehensive strategies/plans for bioinformatics software development leading to high-quality, robust applications.</li><li style="color: rgb(45,45,45);line-height: normal;">Work with the bioinformatics research team to understand functional specifications, identify, design, implement, and test sequence analysis software including alignment, variant calling, and annotation software.</li><li style="color: rgb(45,45,45);line-height: normal;">Design architecture, build, and deploy to production data-intensive applications aimed at the analysis of large genomic data.</li><li style="color: rgb(45,45,45);line-height: normal;">Apply software engineering best practices to update bioinformatics pipelines and transition them from research to production.</li><li style="line-height: normal;">Work with cross-functional teams, and support integration and regression testing of bioinformatics software and cloud-based distributed computational systems.</li><li style="color: rgb(45,45,45);line-height: normal;">Prepare documentation and specifications of bioinformatics products and services.</li><li style="color: rgb(45,45,45);line-height: normal;">Report, track, and escalate anomalies discovered during data analysis or software testing (all phases) and ensure closure on issues.</li></ul>Qualifications: <ul><li style="line-height: normal;"> BS or higher in bioinformatics, computer science, or related field.</li><li style="line-height: normal;"> 4+ years of experience developing algorithms and pipelines for computationally intensive distributed applications and bioinformatics analysis.</li><li style="line-height: normal;"> 4+ years of experience working with data from a range of genomics and molecular biology technologies. Strong understanding of sequencing data, annotations, and standard bioinformatics tools e.g. bwa, samtools, picard, etc.</li><li style="line-height: normal;"> Expert knowledge of Python.</li><li style="line-height: normal;"> 2+ years of experience with SQL and relational databases like PostgreSQL/MySQL/Oracle.</li><li style="line-height: normal;"> Working knowledge of managing and deploying Docker containers and container orchestration systems.</li><li style="line-height: normal;"> Experience working with cloud services like AWS, GCP, or similar.</li></ul>Nice to Haves:<ul><li style="line-height: normal;"> Familiarity with R.</li><li style="line-height: normal;"> Experience working in a regulated environment. </li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Senior Bioinformatics Software Engineer

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer!  We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Sr. QA Manager, Upstream Operations to report to the Director of Quality Assurance to continue the advancement of PACT Pharma’s cutting-edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives. What you will do:The ideal candidate is an experienced Quality Assurance leader with a track record of success in ATMP/ GMP operations with experience in bioinformatics, gene editing, and protein science which makes up PACT Pharma's clinical screening process. An understanding of clinical diagnostics, clinical laboratory screening, and autologous clinical processing is desired. The job incumbent will help to build the Quality Assurance program, lead and mentor QA staff that support the following QA activities:  <ul><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Manage review and release of patient screen data to support autologous Cell Therapy clinical production.</li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Provide QA oversight and collaborate with operations to develop quality requirements and streamline the process and documentation to ensure compliance.</li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Partner with operations to build Standard Operating Procedures for process, equipment, and supporting programs.</li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Oversee training programs and materials for clinical screening production staff.</li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Provide Quality insight into QMS processes; Change Control, Deviation/ CAPA generation, Risk Management</li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Review GMP quality metrics. Analyze data relating to process controls, and continuous process improvement efforts. Coordinate with operations for the necessary quality adjustments. </li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Review relevant GMP documents for compliance to company SOPs, quality systems, and regulatory requirements. </li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Provide guidance, interpretation, support, training, and input on the interpretation and implementation of regulations, guidelines, company procedures, and policies. </li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Participate in or lead teams for special projects as assigned. </li><li style="margin-left: 36.7pt;line-height: normal;background: white;"> Develop and work with staff to implement quality process controls relating to all areas of operation, including the following systems: quality, facilities and equipment, materials management, production, packaging, and labeling.  </li></ul>Minimal Qualifications: <ul><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Bachelor’s degree or higher in a relevant scientific discipline – Bioinformatics, Biology, Biochemistry, or Chemistry with 6+ years relevant industrial experience.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> 2 plus years of people management experience is required.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Strong understanding of regulatory inspection and knowledge of their requirements. Ability to build strong working relationships with cross-functional departments.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> The role demands a goal-driven approach and the ability to focus on time-sensitive objectives.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Demonstrated understanding through prior experience of ATMP/ GMP regulation and guidelines related to the conduct of early phase clinical programs. </li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Must have worked in clinical development as a Quality professional for 3+ years and 5+ years total in a GMP environment.  </li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Demonstrated strong problem-solving and decision-making skills.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Strong teamwork, leadership, organization, and communication skills.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Familiarity with molecular and protein clinical screening programs.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Must have extensive cGMP quality system knowledge and experience. </li></ul>Desirable Experience: <ul><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Experience with Master Control eDMS and eQMS is desirable.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> Audit experience and/or certification are desirable.</li><li style="margin-left: 36.75pt;line-height: normal;background: white;"> CLIA experience is a plus.</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Sr. QA Manager, Upstream Operations

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment and work with intelligent people who are making an impact on cancer, you will want to join the PACT Pharma team.  We are a diverse work family with a dynamic and earnest culture. We are an innovative and collaborative workforce working towards one main goal - eradicating cancer! We are located in the San Francisco bay area. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for an Executive Assistant who will report to the Senior Vice President, Clinical Development, and support two other Vice Presidents in our organization to continue advancing PACT’s cutting-edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.Responsibilities:<ul><li style="line-height: normal;">Proactively provide administrative support to members of PACT’s Executive and/or Sr. Management teams</li><li style="line-height: normal;">Coordinate management’s communications, including taking calls, responding to emails, and interfacing with guests</li><li style="line-height: normal;">Schedule and coordinate meetings, appointments, and corporate visits; manage travel and itineraries and assist with expense reporting</li><li style="line-height: normal;">Assist in managing various aspects of Board interactions as well as meeting activity</li><li style="line-height: normal;">Prepare internal and external corporate documents for team members and industry partners</li><li style="line-height: normal;">Own and manage projects of intermediate-complex scope that require good judgment, strong analytical skills, and effective communication</li><li style="line-height: normal;">Assist/manage daily operations of the office with other Executive Assistants including maintaining and stocking office supplies, scanning documents to appropriate departments, distributing mail, stocking snacks and refreshments, and other general office needs.</li><li style="line-height: normal;">Assist with arrangements for corporate events that take place both at and outside of the workplace; such events include off-sites and employee appreciation events</li><li style="line-height: normal;">Complete various ad hoc projects as assigned</li><li style="line-height: normal;">Assist in the development of materials and meeting documents</li><li style="line-height: normal;">Coordination of conference/meeting room set up, catering, and making logistical arrangements </li></ul>  Minimum Qualifications:<ul><li style="line-height: normal;">6+ years of experience as a Sr. Administrative and/or Executive Assistant reporting directly to senior management.</li><li style="line-height: normal;">Must be a team player and provide backup support to other admins and support staff as requested</li><li style="line-height: normal;">Strong multi-tasking skills and ability/desire to wear multiple hats</li><li style="line-height: normal;">Must be able to effectively manage and prioritize workload from multiple client groups</li><li style="line-height: normal;">Must possess strong organizational, project management, and problem-solving skills with impeccable attention to detail and multi-tasking abilities.</li><li style="line-height: normal;">Bachelor’s degree or equivalent required.</li><li style="line-height: normal;">Advanced Microsoft Office skills, with an ability to become familiar with company-specific programs and software.</li><li style="line-height: normal;">Ability to work in a fast-paced collaborative start-up environment as a team player and pitch in where and whenever needed.</li><li style="line-height: normal;">Ability to uphold a strong work ethic and good attitude under pressure.</li><li style="line-height: normal;">The ideal candidate must uphold a strict level of confidentiality, develop and sustain a level of professionalism among staff and visitors and have exceptional interpersonal skills coupled with a friendly and professional demeanor.</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Executive Assistant

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient’s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! We are in the San Francisco bay area, the heart of the world’s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for Sr. Scientist Developmental Analytics reporting to the SVP Process Development. This position will be based in South San Francisco.The candidate will form and lead experimental research performed by RA’s and Scientists in analytical development supporting PACT’s process development and cell manufacturing process.  Furthermore, they will interact closely with Scientists and Research Associates of PACT’s Research and manufacturing team, e.g. QC, for technology transfer.  They will be actively performing experiments and should be highly proficient in state-of-the-art techniques for primary cell culture, molecular and cell analysis, and related instrumentation that will develop and support troubleshooting quantitative, semi-quantitative, and qualitative assays. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment.Responsibilities:<ul><li style="line-height: normal;">Plan strategies and mission to guide the formation of a developmental analytical team</li><li style="line-height: normal;">Participate in the development, qualification, and transfer of quantitative, semi-quantitative bioanalytical and molecular methods to support the current and next-generation cell therapy manufacturing process</li><li style="line-height: normal;">Manages research associate/scientist level team members</li><li style="line-height: normal;">The candidate will interact closely with associated departments to support technology transfer to manufacturing and QC</li><li style="line-height: normal;">Contributes to the development of a department-level strategy to support key goals of the organization</li><li style="line-height: normal;">Present results, conclusions, and implications to project teams and senior management</li><li style="line-height: normal;">Work with outside vendors to evaluate reagents, instrumentation, and software for best-supporting assay development and data generation/analysis</li><li style="line-height: normal;">Author standard test methods and best-practices documents for the assay development group, including reports</li><li style="line-height: normal;">Support of regulatory submissions by authoring/reviewing study reports or CMC sections</li><li style="line-height: normal;">The candidate is expected to maintain rigor and quality of execution, documentation, and timelines</li></ul>Minimum qualifications:  <ul><li style="line-height: normal;">The ideal candidate should hold a Ph.D. with 6+ years’ experience or a master’s degree with 8+ years of experience in T cell biology (or related field)</li><li style="line-height: normal;">Understanding QC assay requirements</li><li style="line-height: normal;">Experience in developing biologic/cellular and molecular assays in the regulated environment to support the following: potency, cell-based-assays, qPCR, digital drop PCR, ELISA, MSD, or other ligand-binding assay technologies</li><li style="line-height: normal;">Prior cell therapy process and assay development experience required (minimum 1 year)</li><li style="line-height: normal;">Demonstrated ability to design, hire, and lead a high performing group of scientists and RAs</li><li style="line-height: normal;">Peer-reviewed publications in the area of assay development are a plus</li><li style="line-height: normal;">Familiarity with cGMP requirements</li><li style="line-height: normal;">The candidate should be highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.</li><li style="line-height: normal;">She/he must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports</li><li style="line-height: normal;">Proven ability to work independently, as well as to collaborate with peers and work effectively in a fast-paced team-oriented environment.</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Sr. Scientist Developmental Analytics

“I joined PACT to work with our impressive management team and innovative technologies to improve cancer therapies. It is the people that make this company exceptional and the mission to cure cancer that motivates me.”

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Director

"I joined PACT because of the science and the people!  PACT is a special place where people work hard because they are passionate about the science, committed to patients, value teamwork and push the boundaries to never accept the status quo. For those who thrive in a fast paced and innovative environment, PACT provides a rewarding opportunity to tackle challenging projects in a collaborative way."

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Vice President

“I joined PACT Pharma because I was energized by the people and the purpose of the organization and have been continuously impressed by the drive and ambition of the whole team to overcome any challenges. Being encouraged to be authentic with one another, and in all of our work, has really built a strong, unified team. This has been a unique and very rewarding experience for me.”

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Associate Director

“When I first interviewed at PACT, I remember being impressed by the collaborative and open nature of research within the company. It left quite the impression with me and ultimately guided me towards choosing a career at PACT. Since joining, I am continually grateful for the level of openness and collaboration between teams and departments that is crucial for pioneering scientific work."


Accelerating CurativeT Cell Therapiesfor Cancer

Tailored for Each and Every Person

PACT Reports New Data Highlighting Predictive Power of Machine Learning Approach Leveraging PACTImmune™ Database at...

Who We Are

Mission & Vision

Our
Platform

Our
Programs

PACT Voices

Director

Technical Operations

Vice President

Program Management

Associate Director

Automation

Scientist

Tumor Immunology

Join Us

QC Associate II / III - Microbiology

Bioprocess Manufacturing Associate II

Accelerating CurativeT Cell Therapiesfor Cancer

Tailored for Each and Every Person

PACT Reports New Data Highlighting Predictive Power of Machine Learning Approach Leveraging PACTImmune™ Database at...

Who We Are

Mission & Vision

OurPlatform

OurPrograms

PACT Voices

Director

Technical Operations

Vice President

Program Management

Associate Director

Automation

Scientist

Tumor Immunology

Join Us

QC Associate II / III - Microbiology

Bioprocess Manufacturing Associate II

Our
Platform

Our
Programs