- The round was led by Vida Ventures, a next generation life science venture firm with industry-leading experience in cell and gene therapy  
- The financing will be used to expand clinical & manufacturing development to deliver clinical data for patients with multiple solid tumor types  

SOUTH SAN FRANCISCO, Calif., Jan. 10, 2020 /PRNewswire/ — PACT Pharma, in pursuit of its vision to eradicate solid tumors using transformational, first-in-class fully personalized NeoTCR-T cell therapies, today announced that it has closed an oversubscribed $75 million Series C financing. This round, led by Vida Ventures, a next generation life science venture firm with industry-leading experience in the cell and gene therapy, also included current investors of PACT.  

Combined with proceeds from previous financings, PACT will use the Series C proceeds to expand the scope of its clinical plan to investigate NeoTCR-T cell products targeting multiple neoantigens for a spectrum of solid tumor types. In addition to clinical expansion, PACT will open in 2020 a next-gen GMP manufacturing facility in South San Francisco to support the end-to-end production and supply chain for the engineering of personalized neoantigen-targeted autologous T cells. Under the direction of industry veteran Tim Moore, President and Chief Technology Officer, PACT will leverage the new in-house manufacturing facility to automate manufacturing and analytic processes to reduce cycle time and manufacturing costs.  

“PACT has grown from company launch to opening its first-in-kind clinical trial in two years. Our progress has been exhilarating and the support from our existing investors has made that progress possible,” said Alex Franzusoff, PhD, Chief Executive Officer of PACT Pharma. “As we look to the next stage of our development and expansion of our clinical programs, we are excited to have interest from a new group of prominent investors who both understand the potential of NeoTCR-T cell therapy and have direct experience in the space. Vida Ventures stood out as a partner of choice, given their depth of operational experience in research, clinical development and manufacturing in cell therapy as well as their proven ability to guide companies like Kite and Allogene across key stages of development.  

As part of the Series C financing, Helen S. Kim, Managing Director at Vida Ventures, will join the Company’s Board of Directors. Ms. Kim brings over 25 years of biotechnology leadership experience and serves on the boards of Assembly Biosciences, Applied Molecular Transport, A2 Biotherapeutics and Exicure, Inc.  

“Our investment in PACT Pharma represents our goal to fund scientific advances by embracing cutting edge innovation with the potential to make a meaningful difference in the lives of patients,” said Kim. “PACT has developed a pioneering platform of personalized designer T cells with the potential to target some of the most elusive solid cancers facing society today.”  

PACT Pharma Raises $75M in Oversubscribed Series C Financing to Develop Fully Personalized NeoTCR-T Cell Therapies for Patients with Cancer

Press Releases

**South San Francisco – January 11, 2021** – PACT Pharma, Inc., a clinical-stage company developing transformational personalized neoTCR-T cell therapies for the eradication of solid tumors, today announced that the company will present at the 39th Annual J.P. Morgan Healthcare Conference, which is being held virtually, on January 11, 2021 at 7:30 a.m. PT/10:30 a.m. ET.  

**About PACT Pharma**

PACT is a clinical-stage biopharmaceutical company pioneering individualized, non-viral precision genome engineered, tumor-specific T cell therapies for the treatment of patients with solid cancers. PACT is now enrolling patients in its first-in-human Phase 1 clinical trial. 

Each person's cancer emerges with a private signature of mutations. PACT identifies these cancer mutation targets (neoantigens) for each person, biochemically verifies and captures T cells from their blood and uses its proprietary, cutting edge (non-viral) precision genome engineering technologies to manufacture a personalized immune cell therapy product for each person with cancer.

For more information please visit[ www.pactpharma.com]( www.pactpharma.com). 


**Media Contact**

Sarah Sutton
Finsbury Glover Hering (FGH)
[ssutton@fgh.com](mailto:ssutton@fgh.com) 
202-337-0808

**Investor Contact**

Uneek Mehra
[umehra@pactpharma.com](mailto:umehra@pactpharma.com)


PACT Pharma to Present at the 39th Annual J.P. Morgan Healthcare Conference

- Garland, former CEO of Portola Pharmaceuticals, to take the helm as PACT’s CEO
- Leadership transition supports PACT’s clinical and corporate progress


**South San Francisco, Calif., March 5, 2021 –** PACT Pharma, Inc., a clinical-stage company pioneering individualized, non-viral precision genome engineered, tumor-specific T cell therapies for the treatment of patients with solid tumors, today announced the appointment of Scott Garland as Chief Executive Officer. Mr. Garland assumes the CEO role effective today, succeeding Alex Franzusoff, Ph.D., who will be staying with the company through mid-year in an advisory role to support the transition. 

“With its cell therapy in clinical trials, PACT is working to rapidly bring its personalized adoptive T cell therapies to patients in need,” said Blake Byers, Ph.D., chairman of PACT’s board and general partner at GV. “As the company’s pipeline progresses, we are committed to adding key competencies to our longstanding strengths in research and development, and Scott’s experience leading the commercial launches of multiple novel therapies will be important for PACT. We thank Alex for his many contributions to the company over the last four years, particularly in guiding the company into clinical development, and wish him the best in his retirement.” 

Mr. Garland was formerly CEO of Portola Pharmaceuticals, which was acquired by Alexion in 2020 for $1.4 billion. At Portola, he led the company through the commercial launch of Andrexxa®, a novel reversal agent for factor Xa inhibitors. Before joining Portola, Mr. Garland held leadership roles at multiple pharmaceutical and biotechnology companies. At Relypsa, he served first as chief commercial officer, then as president overseeing the U.S. commercial launch of Veltassa® for the treatment of hyperkalemia. Prior to Relypsa, Mr. Garland spent three years as chief commercial officer at Exelixis where he built the company’s commercial organization, transitioning Exelixis from a development-stage to a commercial-stage company with the launch of cabozantinib in medullary thyroid cancer. He also spent nine years at Genentech, where he led the commercial franchises for two multi-billion dollar therapies – Avastin® and Rituxan®. Mr. Garland received a Bachelor of Science degree from California Polytechnic State University-San Luis Obispo and a Master’s degree in business administration from the Fuqua School of Business at Duke University.

“I am honored and privileged to join PACT – and its world class team – at this important moment in the company’s growth,” said Mr. Garland. “PACT is well positioned to be a leader in developing personalized anti-cancer T cell therapies against solid tumors. I appreciate the work that Alex has done to build PACT into a clinical-stage biotechnology company and I am delighted at the opportunity to help the company in its efforts to advance cell therapies to benefit patients with solid tumors.”   

“I am very proud of the landmark achievements and progress that the PACT team has made over the past four years in advancing our personalized adoptive T cell therapies, including launching our current clinical program across multiple solid tumor types,” said Dr. Franzusoff. “I am confident that the company is in excellent hands under Scott’s leadership.” 

**About PACT Pharma**

PACT Pharma is a clinical-stage biopharmaceutical company pioneering individualized, non-viral precision genome engineered, tumor-specific T cell therapies for the treatment of patients with solid tumors. PACT Pharma is now enrolling patients in its first-in-human Phase 1 clinical trial. Each person's cancer emerges with a private signature of mutations. PACT Pharma identifies these cancer mutation targets (neoantigens) for each person, biochemically verifies and captures T cells from their blood and uses its proprietary, cutting edge (non-viral) precision genome engineering technologies to manufacture a personalized immune cell therapy product for each person with cancer.



**Media Contact**

Sarah Sutton
Finsbury Glover Hering (FGH)
sarah.sutton@fgh.com
202-337-0808

**Investor Contact**

Uneek Mehra
umehra@pactpharma.com



PACT Pharma Announces Planned Retirement of CEO Alex Franzusoff, Veteran Biotech Executive Scott Garland Named as Successor

PACT is a visionary company pushing the frontiers of science, technology and medicine. We are creating T cell therapies to alter the course of cancer and meaningfully impact the lives of patients who urgently need breakthrough therapies. We are building a team of driven, talented and passionate individuals committed to bringing these novel personalized therapies to people living with cancer.

Join Us

PACT is a clinical stage company dedicated to engineering transformational T cell therapies by enabling each person’s immune response to eradicate their individual cancer.

Who We Are

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for a Quality Assurance Director, Upstream Operations to report to the Vice President of Quality Assurance to continue advancement of PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;What you will do: The ideal candidate is an experienced&nbsp;Quality Assurance leader&nbsp;with a track record of success in ATMP/ GMP&nbsp;operations with experience in bioinformatics, gene editing, and protein science which makes up PACTs clinical screening process. An understanding of clinical diagnostics, clinical laboratory screening and autologous clinical processing is desired. The job incumbent will help to build the Quality Assurance program, lead and mentor QA staff that&nbsp;support&nbsp;the following&nbsp;QA activities:&nbsp;&nbsp;<ul><li>Manage review and release of patient screen data to support autologous Cell Therapy clinical production.</li><li>Provide QA oversight and collaborate with operations to develop quality requirements and streamline the process and documentation to ensure compliance.</li><li>Partner with operations to build Standard Operating Procedures for process, equipment and supporting programs.</li><li>Oversee training program and materials for clinical screening production staff.</li><li>Provide Quality insight into QMS processes; Change Control, Deviation/ CAPA generation, Risk Management</li><li>Review GMP quality metrics. Analyze data relating process controls, and continuous process improvement efforts. Coordinate with operations for the necessary quality adjustments.&nbsp;</li><li>Review relevant GMP documents for compliance to company SOPs, quality systems, and regulatory requirements.&nbsp;</li><li>Build an effective Quality Assurance team to support QA operations</li><li>Provide guidance, interpretation, support, training, and input on the interpretation and implementation of regulations, guidelines, company procedures, and policies.&nbsp;</li><li>Participate in or lead teams for special projects as assigned.&nbsp;</li><li>Develop and work with staff to implement quality process controls relating to all areas of operation, including the following systems: quality, facilities and equipment, materials management, production, packaging, and labeling.&nbsp;&nbsp;</li></ul>Minimal Qualifications:&nbsp;<ul><li> Bachelor&rsquo;s degree or higher in a relevant scientific discipline &ndash; Bioinformatics, Biology, Biochemistry, or Chemistry with minimum of 10 years relevant industrial experience.</li><li> Prior management experience required.</li><li>Extensive experience with regulatory inspection and knowledge of their requirements. Ability to build strong working relationships with cross-functional departments.</li><li>The role demands a goal-driven approach and the ability to focus on time-sensitive objectives.</li><li>Demonstrated understanding through prior experience of ATMP/ GMP regulation and guidelines related to the conduct of early phase clinical programs.&nbsp;</li><li>Must have worked in clinical development as a Quality professional for a minimum of 5+ years and at least 8+ years total in a GMP environment.&nbsp;&nbsp;</li><li> Demonstrated strong problem-solving and decision-making skills.</li><li> Strong teamwork, leadership, organization, and communication skills.</li><li> Extensive cGMP quality system knowledge and experience is required</li><li> Experience with Master Control eDMS and eQMS is desirable </li><li> Audit experience and/or certification is desirable.</li><li> Familiarity with molecular and protein&nbsp;clinical screening programs</li><li>CLIA experience desired</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Corporate (South San Francisco)

Quality Assurance Director - Upstream Operations

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are about eradicating cancer, come join our team!We are currently recruiting for a Scientist-level independent contributor who will join the Gene Editing team&rsquo;s research group and contribute to the advancement of PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;What You Will Do:You will utilize your expertise in molecular and cellular biology to independently generate preclinical and IND-enabling data. The incumbent will develop and optimize gene editing platforms and methods which will be utilized for next-generation T cell therapies. The incumbent will also develop methods to assess off-target and on-target editing. Molecular construct design, validation, data analysis, and regulatory report generation will be key components of your work.You will be responsible for proposing projects, designing experiments, and executing work aimed at improving PACT&rsquo;s cellular product using genetic tools. The incumbent will draw on a deep understanding of T cell biology and oncology, as well as existing therapeutics MoAs, in order to contribute to the team&rsquo;s discussion of which genes or systems should be prioritized and how best to tailor cells to take advantage of the target pathway.Minimal Qualifications:<ul><li>PhD plus 1 to 3 years&rsquo; post-graduate experience</li><li>Demonstrated autonomy in expression vector design and generation</li><li>Experience with primary cell culture and flow cytometry</li><li>Experience in areas related to T cell signaling or T cell biology</li><li>Ability to propose new projects, design proof of concept experiments, and independently execute and analyze the work</li></ul>Preferred Qualifications: <ul><li>Industry experience</li><li>Direct experience with molecular cloning</li><li>Direct experience designing and performing assays using ddPCR or real-time PCR</li><li>Direct experience drafting technical reports and documents for inclusion in regulatory submissions</li><li>A deep understanding of natural and synthetic gene regulatory elements that act at the DNA, RNA, and protein levels</li><li>Expertise in cutting-edge gene editing technologies and/or therapeutic cell products, and analysis methods for engineering outcomes</li><li>Ability to select and utilize informatics tools for analyzing large and/or complex datasets such as NGS, and correlating data with a variety of variables and outcomes.</li><li>Experience designing and conducting novel genetic screens</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Scientist - Gene Editing/Molecular Biology

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;&nbsp;We are currently recruiting for a&nbsp;Senior Process&nbsp;Engineer&nbsp;who&nbsp;will report to the Associate Director of Process Engineering and be responsible for assessing&nbsp;requirements ,deploying&nbsp;capital equipment and technical infrastructure solutions, and assessing effectiveness across broad range of production processes.&nbsp;The ideal candidate&nbsp;should be creative and interdisciplinary with practical problem-solving skills and hands-on experience in the areas of biologics manufacturing, laboratory automation, liquid handling, and instrumentation qualification and validation. This will be a unique opportunity to see your solutions transform the way we process patient samples, improving PACT&rsquo;s throughput and turnaround time, and directly impact patient lives.&nbsp;Responsibilities:&nbsp;<ul><li>Work with the operations and process development teams to fully map and understand process timings, material flow, hands-on-time, cost, quality, and throughput&nbsp;</li><li>Design and execute studies and data gathering exercises for new and existing protocols to characterize instrumentation and assay performance and improve reproducibility and reliability&nbsp;</li><li>Work with the software and automation engineering teams to develop and deploy automated software and robotic solutions throughout the production lab&nbsp;</li><li>Work with end users to understand and document requirements and validate that those requirements are met through verification and validation&nbsp;</li><li>Coordinate the project lifecycle in partnership with PMO and Quality to define solutions, run FMEAs, and ensure the systems that you deploy are fit for purpose&nbsp;</li><li>Identify continuous improvement projects as well as opportunities for technological innovation and process development&nbsp;</li><li>Author equipment documentation, SOPs, and work instructions in accordance with PACT&rsquo;s quality management system&nbsp;</li><li>Communicate clearly and concisely, both verbally and in the form of written reports&nbsp;</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s or master&rsquo;s degree with 5+ years of process engineering experience in pharmaceutical or biotech&nbsp;</li><li>&nbsp;3+ years&rsquo; experience investigating, developing, and implementing new manufacturing processes and improving existing processes&nbsp;in the areas of biologics manufacturing&nbsp;</li><li>Experience operating within a formal quality management system such as cGMP or ISO 13485 and familiarity with 21 CFR part 11 is required&nbsp;</li><li>Experience&nbsp;developing, implementing and improving manufacturing line layouts and processes in an automated laboratory setting&nbsp;</li><li>Strong understanding and knowledge of Lean manufacturing concepts (pFMEA, Value Stream Mapping, Kaizen, 5S, 6-sigma)&nbsp;</li><li>Experience integrating laboratory processes and equipment into LIMS, informatics, MES or data management systems&nbsp;</li><li>Ability to analyze and manipulate complex scientific and operational datasets and to communicate findings/recommendations&nbsp;</li><li>Experience implementing IQ/OQ/PQs and understanding of process performance qualifications&nbsp;</li><li>Familiarity with formal process validation and/or v-model life cycle development&nbsp;</li><li>Experience operating within a turnaround time sensitive production environment&nbsp;</li><li>Highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives&nbsp;</li><li>Experience with plasmid and cell manufacturing is a plus&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status. &nbsp;

Senior Process Engineer

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for an Associate Director of Engineering and Facilities who will report to Senior Director, Manufacturing Operations, and continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.We are seeking a seasoned GMP facilities operations management leader with biotech industry or pharmaceutical industry facilities operations and engineering expertise with a solid technical foundation in engineering.Responsibilities:<ul><li>Provide oversight for facilities, engineering risk management, buildings and properties with direct updates to the executive management team</li><li>Manage and lead capital engineering projects and spend</li><li>Be responsible for IQ/OQ/PQ, commissioning, qualification and validation of GMP facilities and equipment</li><li>Implement and manage CCMS (Computerized maintenance management system), work order system, equipment asset management, and predictive maintenance/reliability engineering</li><li>Meet or exceed customer service and internal department&rsquo;s KPIs performance</li><li>Ensure effective communication and project plan alignment between business stakeholders, users, Facilities Operations, maintenance, site services, securities, IT, Procurement, Finance, Legal, HR, and all departments regarding all facilities operation&rsquo;s issues</li><li>Oversee and manage direct reports and third-party service providers to ensure compliance.</li><li>Manage the direct relationship with landlords and/or property Managers, to ensure correct building maintenance and compliance with the agreements signed in the lease contract</li><li>Oversee EHS for the company and ensure compliance</li><li>Ensure compliance with company policy for procurement of facilities services and goods as well as local law and regulations (Building Taxes, Health and Safety)&nbsp;</li></ul>Qualifications:<ul><li> BS or MS in Engineering or related field with 8+ years&rsquo; experience in GMP facilities expansion and operational management of office space, GMP facilities maintenance, utility systems (water, air, HVAC, etc.), and equipment management </li><li> Proven track record of establishing and managing a robust CCMS (Computerized maintenance management system), work order system, predictive maintenance / reliability engineering</li><li> Expertise in FDA cGMP regulations and requirements for manufacturing-facility utilities that includes understanding of cGMP compliance within controlled space </li><li> Experience managing large capital engineering projects and facilities in a corporate environment</li><li> Experience with a biotech/pharma would be desirable, cell therapy is a plus</li><li> Familiar with the Quality Compliance system is desirable</li><li>Must be able to work on highly complex problems in a variety of situations where analysis is required. Solve problems using considerable and rational judgment, leading to routine and specific recommendations</li><li>Good track record of building and leading high performing team</li><li>Excellent English verbal and written communications skills</li><li>Proven ability to achieve results through positive influence in a matrix environment</li><li>Experience managing budgets and ensure projects stay within budget and timeline</li><li>Experience in the following areas; EH&amp;S, IOP/Q as well as Plant/Equipment commissioning, qualification and validation&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Associate Director, Engineering and Facilities

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Research Associate II / SRA&nbsp;who will report to the Associate Director of Laboratory Operations. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;The individual will be responsible for the execution of high-throughput workflows and will be involved in the critical path for the discovery of neoEpitope and corresponding cognate TCRs. The position involves a considerable amount of bench work in a GMP-like environment and will on protocols and SOP executions to support our clinical trial. The ideal candidate should have keen attention to details, be highly organized and should enjoy operating in an exceptionally dynamic and collaborative environment.&nbsp;Qualifications:<ul><li>Bachelor&rsquo;s degree with 2-5 years of industry experience in Molecular Biology or related disciplines.</li><li>Must have industry experience in a production or operations setting.</li><li>Prior experience with mammalian cell culture and cell handling (human, mammalian, or T cells)</li><li>Hands on experience with two of the following:&nbsp; nucleic acid purification, molecular cloning, gene editing, protein purification, protein expression, flow cytometry, PCR, NGS, cell based assays.</li><li>Experience working with liquid handlers and laboratory automation is a plus.</li><li>Acute attention to details, well-organized, diligent with documentation. Able to follow SOPs, troubleshoot problems, and have knowledge of continuous improvement practices.</li><li>Highly goal-driven and the displays the ability to handle delicate experiments in a timely manner.</li><li>Able to operate in a collaborative environment and communicate clearly and concisely, both verbally and in the form of written reports.</li><li>Shift &amp; Hours: Moving to 7 day operational work week. Must be able to work one of the following shifts:&nbsp; Monday - Friday, Tuesday - Saturday, Wednesday - Sunday.</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Research Associate II / SRA

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for a Sr. Automation Engineer - Liquid Handling specializing in automation &amp; applications engineering who will report to the Chief Technology Officer and continue advancing PACT&rsquo;s patient-specific product development pipeline. The incumbent should be creative and interdisciplinary with practical problem-solving skills and hands-on experience in the areas of laboratory automation, liquid handling, design of experiment and instrumentation qualification and validation. This will be a unique opportunity to see your solutions transform the way we process patient samples, improving PACT&rsquo;s throughput and turnaround time and directly impact patient lives.&nbsp;What You Will Do:The incumbent will draw on their experience in laboratory automation and liquid handling to create robust automated production processes across a range of scientific disciplines and throughout the company. This individual will need to have a deep understanding of liquid handling and laboratory automation principals and be able to spearhead innovative workflow solutions to complex biological problems. He or she will partner closely with scientific subject matter experts as well as automation, software and process engineers to scale and streamline PACT&rsquo;s processes.&nbsp;Minimal Qualifications:<ul><li>BS degree with a minimum of 5 years hands-on industry experience focused on liquid handlers and lab automation.</li><li>Experience with Hamilton Microlab Star / Venus</li><li>Experience creating scripts to integrate and control automation equipment</li><li>Extensive experience quantifying and qualifying your work through IQ/OQ/PQ</li><li>Experience integrating laboratory equipment into laboratory information management systems (LIMS)</li><li>Highly goal-driven and have demonstrated the ability to effectively prioritize and focus on time-sensitive objectives&nbsp;</li></ul>Preferred Qualifications: <ul><li>MS or PhD with a minimum of 7 years of self-directed application development</li><li>5 + years of experience investigating, developing, and implementing laboratory or manufacturing processes</li><li>Broad experience with multiple liquid handling platforms: Hamilton, Tecan, Beckman, Agilent etc.</li><li>Experience with instrument integrations and scheduling software</li><li>Experience developing and deploying methods in a regulated environment (GxP/CLIA/CAP)</li><li>Hands-on experience with bacterial and/or mammalian cell culture, protein and nucleic acid purification, microfluidics and genome engineering platforms (e.g. CRISPR, TALENs).</li></ul>&nbsp;&nbsp;PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Senior Automation Engineer

PACT Pharma&nbsp;is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. &nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! &nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. &nbsp;We are currently recruiting for a&nbsp;Director, Laboratory Operations&nbsp;who will report to the VP of Operations and anchor a newly formed production team focused on operationalizing&nbsp;and centralizing sequencing workflows at PACT. This will be a unique opportunity to design and implement new operational processes and see your contributions to PACT&rsquo;s personalized therapy directly translate into the clinic and impact patient lives.&nbsp;The person in this role will be responsible for&nbsp;building and operationalizing a core sequencing laboratory focused on&nbsp;Next-generation Sequencing (NGS) analysis of single T cells. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.&nbsp;Responsibilities:&nbsp;<ul><li>Lead, mentor, and grow a team of scientists and research associates responsible for processing clinical&nbsp;samples</li><li>Serve as the sole point of contact and process owner for the&nbsp;sequencing workstream&nbsp;portion of PACT&rsquo;s production pipeline.</li><li>Define and implement operational protocols and best practices.</li><li>Manage workflows, materials, and resources to ensure the quality and timely delivery of patient-specific reagent libraries&nbsp;and&nbsp;DNA NGS libraries.</li><li>Oversee processes to identify and implement process improvements focused on quality, turnaround time, and cost.</li><li>Collaborate with process development and engineering to scale your operation by automating wherever possible.</li><li>Author SOPs and work instructions in accordance with PACT&rsquo;s quality management system and provide data for regulatory documentation to support clinical development.</li><li>Manage CRO providers for sequencing and data&nbsp;delivery</li><li> Lead efforts to analyze data and write reports to inform therapeutic candidate selection for our clinical patients.</li></ul>Qualifications:&nbsp;<ul><li>Master&rsquo;s degree with&nbsp;10+ years of experience or Ph.D. with&nbsp;5+ years of industry experience with a career focus in cell or molecular biology, biochemistry, or molecular genetics.</li><li>5+ years&rsquo; experience managing a production laboratory&nbsp;operation</li><li>Experience with&nbsp;single cell sequencing, next-gen&nbsp;sequencing,&nbsp;and&nbsp;laboratory automation.</li><li>Experience operating within a formal quality management system. cGMP or ISO 13485 production experience is a plus.</li><li>Communicate clearly and concisely, both verbally and in the form of written reports.</li><li>Demonstrated leadership skills and teamwork.</li><li>Demonstrated ability to implement laboratory best practices, continuous improvement methodologies, and lean manufacturing principles.</li><li>Highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives.</li><li>Experience in a turnaround time-sensitive production environment is a plus.</li><li>Experience with complex LIMS, informatics, or data management is a plus.</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate&nbsp;on the basis of&nbsp;race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Director, Laboratory Operations, NGS Core

PACT Pharma&nbsp;is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;In principle, this technology can be used to treat any cancer type.&nbsp;&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently searching for a&nbsp;Process Development Senior Scientist II who will report to the Director of Process Development within our TCR discovery and validation group.The ideal candidate should be creative and interdisciplinary with practical problem-solving skills and hands-on experience in the areas of molecular cloning, nucleic acid purification, and non-viral gene editing technologies as well as experience scaling and automating these technologies.This will be a unique opportunity to improve and operationalize PACT&rsquo;s cutting-edge personalized TCR discovery process and see our clinical pipeline through to commercial launch while having a direct impact on patient lives.&nbsp;Responsibilities:<ul><li>Provide scientific expertise to the entire process development team in the areas of molecular cloning and gene editing technologies</li><li>Work in collaboration with R&amp;D, software engineering, automation engineering, QA, and production to develop and deploy high-throughput laboratory automation and software solutions with thorough process controls</li><li>Develop, qualify, and implement processes that improve key operational metrics including robustness, reliability, turn-around-time, quality, and cost</li><li>Identify and prioritize projects, draft proposals, and communicate the feasibility of proposed solutions</li><li>Apply Quality-by-Design principles to define robust, integrated control strategies</li><li>Lead troubleshooting efforts using recognized tools to ensure high production pipeline availability and continuous quality</li></ul>Qualifications:<ul><li>Ph.D. degree or equivalent, in cell or molecular biology, bioengineering, or other relevant biological sciences or engineering disciplines</li><li>10+ years of relevant experience helping to develop and implement production workflows for molecular cloning and/or non-viral gene editing technologies such as CRISPR / Cas9</li><li>Ability to propose new projects, design proof of concept experiments, and lead the execution and analysis of the work</li><li>Hands-on experience with bacterial and/or mammalian cell culture, and/or nucleic acid workflows</li><li>Experience carrying out process characterization to identify and control sources of variability using designed experiments and statistical tools</li><li>Experience in systematic troubleshooting and root case analysis in a production environment using recognized tools</li><li>Experience developing and characterizing the performance of analytical and functional test methods to ensure quality</li><li>Experience designing and executing validation plans for equipment, processes, and test methods</li><li>Innovative, motivated, and independent leader with a willingness to spend significant hands-on time coaching and mentoring team members</li><li>Highly goal-driven and have demonstrated the ability to effectively prioritize and focus on time-sensitive objectives</li><li>Experience operating within a formal quality management system such as CLIA, ISO 13485, or CFR 211</li><li>Communicate clearly and concisely, both verbally and in the form of written reports</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Senior Scientist II, Process Development

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for an Associate Director of Reagent Manufacturing who will report to the VP of Operations and continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp; This person will oversee and lead all aspects of Reagent Manufacturing in a for PACT Pharma internal production and testing. They will have the required experience and drive to scale a small pilot operation to support rapid volume growth, oversite of CMO partners, and enhancing the existing processes and infrastructure to deliver robust and high-quality products to internal customers. This detail oriented and process focused leader will leverage best practices and industry leading approaches to ensure production schedules are met while achieving critical cost and quality objectives. The ideal candidate will be action oriented and fluent in the setup and operation of regent operations including workflow optimization, QC method implementation, process validation, and efficient inventory utilization.Responsibilities: <ul><li>Manage the overall process of formulation, QC, and packaging resources</li><li>Ensure compliance to quality system requirements</li><li>Create required documentation: protocols, test reports, SOPs, product specifications, manufacturing controls, and performance verifications</li><li>Develop and maintain a roadmap to build schedule to meet internal and external consumables demand</li><li>Work with internal cross-functional teams to ensure a continuous product supply and maintain procedural control of the entire reagent supply chain</li><li>Oversee the scale up of production processes in an efficient and cost-effective manner</li><li>Assist the transfer of new products or processes into Manufacturing</li><li>Participate in new vendor evaluation, qualification, and integration</li><li>Supervise, develop, and mentor of direct reports</li></ul>Qualifications:<ul><li>Bachelor's degree in Biology, Chemistry, or related field or comparable industry experience with 10+ years of experience in manufacturing of life sciences reagents for use in research and clinical applications</li><li>Extensive knowledge of manufacturing work center administration; including BoM management, routing hours, and resource scheduling</li><li>Candidates with advanced degrees will be preferred</li><li>Significant experience in production of molecular biology products</li><li>Proficient with scaling and automating production</li><li>Understanding of Quality Control methods development and implementation</li><li>Ability to drive supply chain, production planning, and inventory management of complex multi-level reagent kits</li><li>Working understanding of statistical methods used in characterization and process control</li><li>Application of LEAN and Six Sigma principals in a reagent manufacturing setting</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;&nbsp;

Associate Director, Reagent Manufacturing

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. We are currently recruiting for an Associate Director, Computer Validation Systems and Data Integrity who will continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives. This individual will be responsible for software quality oversight and execution of system validation and verification efforts supporting computerized systems (including equipment/instruments with a computer component) ensuring compliance to quality objectives and regulatory requirements. Responsibilities:<ul><li>Provide Software QA and validation leadership for GXP computerized systems and applies risk-based methodology to validation/qualification efforts in compliance with 21 CFR Part 11, EU Annex 11, and GAMP 5</li><li>Oversee and execute software QA and validation strategy in support of custom software systems, COTS configuration, workflow, and/or analytics to improve the overall accuracy, efficiency, and effectiveness of the electronic computerized system</li><li>Manage and provide guidance to system testing personnel in the organizing and prioritizing daily tasks, performing training, and writing performance reviews</li><li>Effectively identify and resolve complex system issues and appropriately communicates gating items to senior management and stakeholders</li><li>Participate and support the external audit program for vendors related to GXP computerized systems</li><li>Participate and be the Software QA and Computer system validation SME in cross-functional project teams</li><li>Evaluate and recommend QA process changes by keeping abreast of the requirements for compliance in own area of work</li><li>Provide training on regulatory issues affecting own area of work</li></ul>Qualifications:<ul><li>B.S. degree in Computer Science or related field with 10+ years of relevant progressive experience, preferably within the pharmaceutical/biotech industry</li><li>At least 5 years of supervisory/personnel management experience</li><li>Comprehensive expertise and working knowledge of GxP, 21 CFR Parts 11 compliance requirements</li><li>Experience in providing oversight in implementing and maintaining GXP computer systems in a validated state</li><li>Strong working knowledge in validation methodology (including GAMP) and software development life cycle (SDLC) principles</li><li>Proven experience managing software validation teams</li><li>Proven experience developing automated test systems and scripts beyond record and playback. Specifically developing functions, adding control flow logic, loops etc.</li><li>Demonstrated experience with Selenium, Cucumber, or similar</li><li>Extensive experience with testing framework e.g. Junit, TestNG</li><li>Excellent verbal, written and interpersonal communication skills</li><li>Effective time management and interpersonal skills</li><li>Strong organizational skills, planning skills and must work effectively within teams.</li><li>Must work effectively within teams with rapidly changing priorities</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;&nbsp;

Associate Director, Computer Systems Validation and Data Integrity

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco Bay Area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are about eradicating cancer, come join our team!&nbsp;We are currently recruiting for Biostatistician who will report to the Senior Developmental Analytics Scientist and continue advancing PACT&rsquo;s cutting edge engineered cell therapy product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives. This position provides statistical support for all phases of manufacturing development. This position will be based in South San Francisco.&nbsp;This role will involve close interaction with Scientists and Directors of the PACT&rsquo;s Process Development team, MSAT, QC, and Bioinformatics. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment. Responsibilities:<ul><li> Design, develop, and apply computational and statistical methods to model complex biological processes (cell therapy manufacturing process, etc.) and analyze our novel complex datasets, including flow cytometry data, metabolic analysis, single-cell sequencing, clinical information, and more</li><li> Provide written and verbal recommendations on statistical and data management issues</li><li>Collaborate on study protocol development for statistical methodology selection, sample size justification, and protocol acceptance criteria</li><li>Generate analysis datasets, tables, figures, and listings to support the analysis of process development and clinical trial data using SAS or JMP</li><li> Author statistical analysis plans, including the development of table and listing shells</li><li> Perform quality control for SAS programs and other study documents (e.g., presentations and reports).</li><li>Provide training to non-statisticians</li><li> Provide support to supplemental or exploratory analyses for regulatory agencies or any other internal and external ad-hoc requests</li><li> Review output across programs to ensure consistency</li><li>Prepare statistical sections of process development or clinical study reports</li></ul>Qualifications:<ul><li>MS with 4+ years of relevant experience or Ph.D. with 2+ year of relevant experience in Statistics, Biostatistics, Mathematics, or equivalent</li><li>Proficiency in statistical analysis software, including SAS, JMP, R, S-Plus, etc.</li><li>Experience with computational biology, genomics, statistical and&nbsp;machine learning&nbsp;optimization techniques&nbsp;for large complex datasets</li><li>Ability to communicate clearly and concisely, both verbally and in the form of written reports</li><li>Effective in solving and communicating complex issues to relevant stakeholders</li><li>Excellent organizational skills, time management, and ability to coordinate workload and meet established deadlines</li><li>Passionate about data integrity, quality assurance, and documentation</li><li>A clear understanding of T cell biology and tumor immunology is a plus&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Biostatistician – Developmental Analytics

PACT Pharma&nbsp;is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient's individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world's premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for a Senior Research Associate in Tumor Immunology&nbsp;who will report to the Scientist and continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;What you will do:&nbsp;The person in this role will be responsible for performing immunological assays and contributing to discovery research programs for next-generation T cell therapies for cancer. The candidate should enjoy operating in an exceptionally dynamic and cooperative environment and will collaborate with a larger cross-disciplinary team of immunologists, biologists, engineers, and bio-informaticians.&nbsp;Responsibilities:<ul><li>Perform ex vivo T cell functional assays according to established procedures</li><li>Perform flow cytometry, ELISA, cell culture, and other cell-based assays</li><li>Experience with molecular biology</li><li>Contribute to generating pre-clinical data to support IND filing</li><li>Accurately document experimental procedures and data in electronic lab notebooks</li><li>Analyze and compile data; communicate research findings to the group and company in the form of written reports and/or oral presentations&nbsp;</li></ul>Minimum Qualifications:<ul><li>Bachelor&rsquo;s or Master&rsquo;s degree in Immunology, Cell or Molecular Biology, Genetics, Biology, Biochemistry, or related discipline</li><li>2+ years of experience if holding a master&rsquo;s degree and 3+ years of experience if holding a bachelor&rsquo;s degree</li><li>Experience with culturing primary human cells and/or cell lines</li><li>Experience with flow cytometry, ELISA, and cell-based assays</li><li>Able to follow detailed procedures</li><li>Ability to focus on deliverables and have demonstrated the ability to prioritize time-sensitive objectives</li><li>Adept at working independently and in a collaborative team environment</li><li>Excellent organizational skills and able to communicate clearly and concisely, both verbally and in the form of written reports&nbsp;</li></ul>Preferred Qualifications:<ul><li>Working knowledge of common molecular techniques such as PCR, cloning, RNA extraction and CRISPR/Cas9</li><li>Experience with R/Python and analysis of large scale transcriptomic and epigenetic datasets (e.g. from scRNAseq, ATAC-seq, and/or CITE-seq)</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Senior Research Associate -  Tumor Immunology

<div></div><div>PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient's individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are about eradicating cancer, come join our team!We are currently recruiting for&nbsp;a Quality Assurance Validation Engineer &ndash; Informatics / Equipment Automation professional, reporting to the Quality Assurance Senior Validation Engineer. This position will be based in&nbsp;South San Francisco.&nbsp;The ideal candidate is an experienced Quality Assurance Validation Engineer with experience in working with COTS and custom programs in early phase clinical environments to provide compliance oversight in support of software and infrastructure designed to support automated processing.Responsibilities:<ul><li>Act as a representative for custom internal Automation equipment projects</li><li>Support in building quality management systems necessary for compliant software development, validation, and verification as described in current GAMP guidance</li><li>Review requirements, specifications, technical design documents, and summary reports to provide timely feedback.</li><li>Work with&nbsp;PACT&nbsp;team on regulatory,&nbsp;quality compliance strategies and execution&nbsp;in support of&nbsp;Upstream operations&nbsp;automation.</li><li>Review and update test protocols&nbsp;according to GAMP / 21 CFR Part 11 standard.</li><li>Participate in automation equipment qualification and provide quality guidance for developing User Requirement and Risk Assessment documentation and drafts of IQ/OQ/PQ Protocols/Reports for Equipment Lifecycle Management.</li><li>Help to establish quality processes within the automation team, including risk assessment, test strategy and plan, execution of test cases, tracing requirements, and other standard operating procedures and work instructions.</li><li>Works with stakeholders to assist with change controls and computer systems validation documents including Impact Assessments, Action Plans, and Risk Assessments, Protocols, and Reports.</li><li>Support software vendor qualification activities including risk assessments and due diligence audits.</li><li>Provide support during inspections and audits.&nbsp;</li></ul>Qualifications:<ul><li>B.S. degree in computer sciences or related field with 5+ years of quality assurance in biotech or pharma industry.</li><li>Experience in Quality oversight of GMP computer systems and Bio-Tech automation field and understanding of quality risk management principles.</li><li>Experience in GAMP5, 21 CFR Part 11, Annex 11.</li><li>Solid Knowledge of IQ/OQ/PQ.</li><li>Experience in GXP Environment.</li><li>Experience with implementation and continuous improvement of Quality Systems supporting CSV.</li><li>Experience with vendor audits.</li><li>Experience with implementation and validation of computer systems to support a new facility design, commissioning, qualification.</li><li>Ability to communicate well across different disciplines and experience levels.</li><li>Experience supporting regulatory inspections.</li><li>Experience using risk management tools (FMEA, etc.).</li><li>Knowledgeable in Software Development Lifecycle (SDLC).&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;</div>

Quality Assurance Validation Engineer

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for Cell Therapy Specialists. This position will be based in South San Francisco.&nbsp;Responsibilities:Under the supervision of the Supervisor/ Manager, the Cell Therapy Specialist will have the opportunity to participate in both manufacturing processes of immunotherapy cell products within a GMP environment, with the main focus in Cell Manufacturing. The duties of this position will primarily consist of manufacturing primary human cells including activities such as culture media preparation, culture processing and management, and cryopreservation.&nbsp; Furthermore, you will be responsible for completing successful qualifications and ongoing support procedures for cleanroom operations and assisting in the development, writing, and review of SOPs, material specifications, standard manufacturing procedures, batch records, and other GMP documentation. The ideal candidate must have a collaborative and inquisitive nature, must possess excellent organizational and verbal, and written communication skills, and be flexible in their working hours.&nbsp;&nbsp;<ul><li>Perform required processing required to produce and assess safe and efficacious products</li><li>Proficiently functions within ISO cleanroom environments, ensuring personal and product safety</li><li>Operate with proper aseptic technique when handling all product and materials</li><li>Consistently produce a high level of documentation accuracy and clarity</li><li>Perform programmed cell operations using specific equipment and closed systems</li><li>Perform cryopreservation of products using controlled-rate freezers</li><li>Proficiently operate and maintain equipment according to designed procedures</li><li>Process products according to established standard operating procedures and batch records</li><li>Work cross-functionally with different groups to support clinical trial studies</li><li>Complete quality records in a timely manner&nbsp;</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s degree or associate degree in a biologics, biotechnology, or related field preferred</li><li>A minimum of 2 years of applicable experience in a clinical laboratory, hematology, blood banking, immunology, or cGMP manufacturing</li><li>Experience in cell culture processing and cleanroom required</li><li>Experience in cell counting and cell selection operation preferred</li><li>Strong work ethic, methodical approach to new challenges</li><li>Must be able to work as a team, as well as independently with minimal supervision</li><li>Demonstrates tact and courtesy in dealing with others</li><li>Excellent organizational skills and attention to detail</li><li>Good verbal and written communication skills</li><li>Skills in Microsoft Office (Excel, Word) preferred</li><li>Able to adapt to company growth and evolving responsibilities</li><li> Ability to work a flexible schedule that may include nights, weekends, and/or holidays</li></ul>Physical Demands:The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of the job. While performing the duties of this job, the employee is frequently required to stand; walk; sit; bend; stretch; use hands to finger, handle or feel; reach with hands and arms, and talk or hear. The employee is regularly required to climb or balance; stoop, kneel, or crouch. The employee is frequently required to lift and/or move up to 30 pounds. Non-absorbent laboratory coats are required, as well as latex (or a non-latex substitute) gloves. When working with potentially hazardous materials that may spray, aerosol, or otherwise contact skin or mucous membranes, face shields or goggles must be worn. Heavy cryo gloves must be used when working with liquid nitrogen.&nbsp;&nbsp;PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Cell Therapy Specialist

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for a Production Specialist who will report to the Manufacturing Supervisor and continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;Responsibilities:Under the supervision of the Supervisor/ Manager, the Production Specialist will have the opportunity to participate in both manufacturing processes of immunotherapy cell products within a GMP environment, with the main focus in Plasmid Manufacturing. The duties of this position will primarily consist of manufacturing plasmids including activities such as bacterial culture management, and downstream purification (Ion Exchange Chromatography, Hydrophobic Interaction Chromatography, Tangential Flow Filtration).&nbsp; Furthermore, you will be responsible for completing successful qualifications and ongoing support procedures for cleanroom operations and assisting in the development, writing, and review of SOPs, material specifications, standard manufacturing procedures, batch records, and other GMP documentation. The ideal candidate must have a collaborative and inquisitive nature, must possess excellent organizational and verbal and written communication skills, and be flexible in their working hours.&nbsp;&nbsp;<ul><li>Perform required processing and manipulations required to produce and assess safe and efficacious products</li><li>Proficiently functions within ISO cleanroom environments, ensuring personal and product safety</li><li>Operate with the proper aseptic technique when handling all product and materials</li><li>Consistently produce a high level of documentation accuracy and clarity</li><li>Perform programmed microbial operations using specific equipment and closed systems</li><li>Proficiently operate and maintain equipment according to designed procedures</li><li>Manipulate products according to established standard operating procedures and batch records</li><li>Participating in clinical trial support and studies may include but are not limited to sample preparation, sample shipping, media, and reagent preparation.</li><li>Conduct and complete investigations for deviations in a timely manner&nbsp;</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s degree or associate degree in a biologics, biotechnology, or related field preferred</li><li>A minimum of 2 years of applicable experience in the life science industry or cGMP manufacturing</li><li>Experience working with bioreactors or fermentation operation preferred</li><li>Experience working with chromatography and filtration operation preferred</li><li>Aseptic processing and clean room experience required</li><li>Strong work ethic, methodical approach to new challenges</li><li>Must be able to work as a team, as well as independently with minimal supervision</li><li>Demonstrates tact and courtesy in dealing with others</li><li>Excellent organizational skills and attention to detail</li><li>Good verbal and written communication skills</li><li>Skills in Microsoft Office (Excel, Word) preferred</li><li>Able to adapt to company growth and evolving responsibilities</li><li>Ability to work a flexible schedule that may include nights, weekends, and/or holidays</li></ul>Physical Demands:The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of the job. While performing the duties of this job, the employee is frequently required to stand; walk; sit; bend; stretch; use hands to finger, handle or feel; reach with hands and arms; and talk or hear. The employee is regularly required to climb or balance; stoop, kneel, or crouch. The employee is frequently required to lift and/or move up to 30 pounds. Non-absorbent laboratory coats are required, as well as latex (or a non-latex substitute) gloves. When working with potentially hazardous materials that may spray, aerosol, or otherwise contact skin or mucous membranes, face shields or goggles must be worn. Heavy cryo gloves must be used when working with liquid nitrogen.&nbsp;&nbsp;PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Production Specialist - Temp to Hire

PACT Pharma&nbsp;is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for a&nbsp;Scientist who will join the Tumor Immunology team&rsquo;s research group and contribute to the advancement of PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives. The ideal candidate will be experienced in immunology and T cell biology.Responsibilities:&nbsp;<ul><li>Design and execute on completion of critical path studies to identify TCR requirements for optimal functional avidity and the T cell profile for the most favorable homing and longevity</li><li>Identify and implement cell-based and biochemical assays to understand the molecular interactions between TCR and peptide-MHC complex</li><li>Collaborate with a larger cross-disciplinary team of immunologists, biologists, engineers, and bio-informaticians for project updates and assessment of studies</li></ul>Qualifications:&nbsp;<ul><li>Ph.D. degree with 2+ years of postdoc or industry experience, with career focus in immunology</li><li>Deep understanding of T-cell receptor biology and biochemistry</li><li>Highly proficient in state-of-the-art techniques for characterizing T cell receptor binding affinities and kinetics</li><li>Experience with assays to evaluate the peptide-MHC-TCR affinity, avidity, and dissociation kinetics</li><li>Highly goal-driven and have demonstrated the ability to focus on time-sensitive objectives</li><li>Ability to operate in a collaborative environment and communicate clearly and concisely, both verbally and in the form of written reports</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status. &nbsp;

Scientist - Tumor Immunology

PACT Pharma is an exciting, well-funded biotechnology company, advancing to clinical studies in 2019 with facilities and laboratories in South San Francisco, CA.&nbsp; PACT is developing personalized adoptive T cell therapies for the eradication of solid tumors.&nbsp; We are in the San Francisco bay area, in the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants.&nbsp;PACT is developing tumor-mutation-targeted T Cells tailored for each patient. Tumor mutation (neoE) targeting is programmed into the patient&rsquo;s own T cells to seek out &amp; kill the tumors. Using (non-viral) precision genome engineering, the neoE-targeted Tcell receptors (TCRs) replace the endogenous TCR of fresh CD8 and CD4 T cells collected from that same patient followed by minimal expansion in closed systems for re-infusion into the patient. These patient-specific neoTCR-P1 cells are formulated to immediately kill all neoantigen-expressing tumors, together with a deep reservoir of &lsquo;ready-to-go&rsquo; neoTCR-P1 cells for long term persistence and capable of rapid expansion to prevent future cancer recurrence.&nbsp;We are currently recruiting for Sr.&nbsp;Quality Assurance Engineer, reporting to the Director, Quality Assurance. This position will be based in South San Francisco.&nbsp;Responsibilities:The ideal candidate is an experienced QA Engineer with a track record of success in GMP environments and understands biologics and/or cell therapy processes (i.e. cell culture, expansion, fill/finish, aseptic environments, reagent/media control, contamination control). The job incumbent will be responsible for the following in support of QA activities:<ul><li>Draft and revise standard operating procedures (SOPs) to support PACT&rsquo;s Quality System.</li><li>Review validation protocols, executed validation studies, and validation summary reports as needed to support GMP manufacturing and laboratory systems.</li><li>Lead Quality initiatives for new GMP Aseptic product and raw material facility construction.&nbsp;</li><li>Partner and drive implementation for GMP new equipment program.&nbsp;</li><li>Review and approve investigations for manufacturing, quality control and other GMP systems. Initiate and manage improvements to programs based on trending or observations.</li><li>Review and approve change control as needed.</li><li>Review equipment maintenance and calibration certificates.</li><li>Provide training and guidance on Quality Assurance topics to foster a quality culture and quality mindset.</li><li>Perform compliance review of internal controls and procedures in PACT&rsquo;s Quality System and ensure alignment with current regulatory requirements.</li><li>Prepare Quality metrics to show the health of PACT&rsquo;s Quality System and make recommendations/improvements in policies and procedures.</li><li>Other functions as necessary for QA under management&rsquo;s discretion and in support of QA systems.</li></ul>Minimal Qualifications:<ul><li>Must have thorough working knowledge of personal computer systems and desktop office applications, including Word, Excel, and PowerPoint. Excellent verbal and written communication skills.</li><li>Ability to build strong working relationships with multiple departments.</li><li>Ideal candidate holds a bachelor&rsquo;s degree or higher in relevant biological sciences.</li><li>The role demands a highly goal-driven approach and the ability to focus on time-sensitive objectives.</li><li>Must have worked for 5+ years in industry with GMP quality assurance experience in a similar environment.&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;&nbsp;

Sr. Quality Assurance Validation Engineer

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team. We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are about eradicating cancer, come join our team!&nbsp;We are currently recruiting for Senior Bioinformatics Systems Engineer, reporting to Associate Director, Software Engineering to continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.What will you do:Great software engineering is vital to a better understanding of biology and winning the war against cancer. At PACT Pharma, we are operating in high gear collecting biological and medical data that will transform our understanding of cancer and will let us develop a better treatment against this disease. We need to build tools to store, process, visualize, explore, and analyze data, which can help us keep pace with the continuously growing number of patients we treat. PACT Pharma is looking for an exceptional Senior Bioinformatics Systems Engineer to join our software engineering group and be a part of the team making this transformation real.<ul><li>Design, develop and maintain scientific data pipelines.</li><li>Work with bioinformatics scientists and engineers to develop test cases that ensure the quality of data analysis pipelines and software applications.</li><li>Participate in requirements and design review meetings to create comprehensive, automated test strategies/plans for bioinformatics software leading to high-quality, robust applications.</li><li>Work with the bioinformatics research team to understand functional specifications, identify, design, and implement test cases for sequence analysis software including alignment, variant calling, and annotation software.</li><li>Participate in tech transfer of data analysis pipelines into the production environment.</li><li>Work with cross-functional teams, and support integration and regression testing of Bioinformatics software.</li><li>Work with the software architecture team to implement CI/CD of data pipelines.</li><li>Execute complex testing of cloud-based distributed computational systems and interpret results independently.</li><li>Simulate bioinformatic data and design, create, and enhance automated testing frameworks to ensure excellent testing coverage.</li><li>Prepare documentation and specifications of bioinformatics products and services.</li><li>Report, track, and escalate anomalies discovered during testing (all phases) and ensure closure on issues.</li></ul>Qualifications:<ul><li>BS or higher in Bioinformatics or related field.</li><li>5+ years of hands-on experience with programming and scripting languages such as Python, Java, C++, shell, and RDBMS (SQL or Oracle).</li><li>Experience working with data from a range of genomics and molecular biology technologies. Strong understanding of sequencing data, annotations, and standard bioinformatics tools e.g. bwa, samtools, picard, etc.</li><li>4+ years of hands-on experience in scripting, running, analyzing, and refining automation frameworks for comprehensive and full application testing, including API testing.</li><li>4+ years of experience in verifying algorithms, workflow or data analysis software.</li><li>Experience in testing bioinformatics software is preferred.</li><li>Experience deploying data pipelines to the cloud with AWS, GCP, or similar cloud services.</li><li>Experience working in a regulated environment.&nbsp;</li></ul>Nice to Haves:<ul><li>Experience with utilizing and designing RESTful interfaces.</li><li>Familiarity with R.&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Senior Bioinformatics Systems Engineer

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently recruiting for QC Associate in the analytical group. &nbsp;This position will be based in South San Francisco.&nbsp;Responsibilities:The QC Associate is responsible for performing testing following written procedure for personalized human T cell therapy product release, stability, and process development.&nbsp; As member of the QC team, the QC Associate contributes to the laboratory operations systems and creating and implementing laboratory operations systems and procedures, to assure the QC laboratory complies with all regulatory requirements.<ul><li>She/he is expected to maintain rigor and high quality of execution and documentation complying with all regulations. Conduct work in accordance with guidelines and requirements established by FDA Good Manufacturing Practices, Code of Federal Regulations, and other regulatory agencies</li><li>She/he must be able to communicate clearly and concisely, both verbally and in the form of written reports, including drafting and review of protocols, SOPs, batch records and regulatory documentation to support clinical development.</li><li>Identify and troubleshoot equipment problems.</li></ul>Minimal Qualifications: <ul><li>The ideal candidate should hold a Bachelor&rsquo;s degree in biological sciences or related field of study.</li><li>Experience in pharmaceutical or biotechnology industry laboratory or in an academic laboratory. Preferred to have hands on experience with molecular biology and immunological analytical methods, such as ELISA, gel electrophoresis, or flow cytometry.&nbsp;</li><li>Candidate should enjoy operating in an exceptionally dynamic and cooperative environment that is goal-driven to achieve time-sensitive objectives.</li><li>Candidate should enjoy operating in an exceptionally dynamic and cooperative environment.</li><li>She/he must be able to communicate clearly and concisely, both verbally and in the form of written reports, laboratory notebooks, and batch records.&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Quality Control Associate (Temp)

PACT Pharma&nbsp;is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are seeking a Senior Program Manager to work in this exciting new area of cancer immunotherapy.&nbsp; This individual will work closely with the Quality Assurance Leadership Team &amp; Operations Functional Leads towards achieving corporate &amp; project goals by providing top notch program &amp; project management expertise.&nbsp; This position will report to the Director of Program Management responsible for Operations and will be based in South San Francisco.What you will do:The Senior Program Manager will be responsible for working closely with PACT&rsquo;s Quality Assurance (QA) Team to advance business critical quality projects centered around building a GMP culture, harmonization by standardization of the quality language across the organization, and supporting workstreams aimed to build out the quality strategy to support commercialization.&nbsp; Ideal candidates should demonstrate strength in meeting facilitation, focus and communication in addition to having a healthcare operations background familiar with working with Quality Systems.&nbsp; This person should have strong business operations and cross-functional management experience.&nbsp;Responsibilities:&nbsp;<ul><li>Provide project management expertise to develop and monitor progress on standardizing Quality language and QA deliverables including policies, procedures, and instructions; Near term projects will focus on Document Control &amp; Retention, Deviations and CAPA management, Validation, Tech Transfer, Training and Risk Assessment</li><li>Manage multiple projects within the constraints of scope, quality, time, and cost, to deliver specified requirements</li><li>Ensure all project requirements and/or objectives are documented. May manage external vendors required for project completion</li><li>Lead cross functional focus groups in partnership with QA to harmonize individual workflows</li><li>Conduct risk-based gap assessment in partnership with QA to define functional remediation plan(s) constructed to meet PACT GMP requirements</li><li>Drive collaboration and coordination across business functions to facilitate the planning process, establishment of goals &amp; milestones, and creation &amp; maintenance of comprehensive timelines that integrate available resources, dependencies, budget, priorities, and other constraints as appropriate</li><li>Develop &amp; maintain PM tools to track overall team progress including project dashboards for Functional Leadership distribution that tracks KPIs</li><li>Ensure project plans and objectives are clearly established and communicated; Collaborate with other Program Managers to integrate timelines and deliverables with the overall project plans</li></ul>&nbsp;Minimal Qualifications:<ul><li>BS/MS with 8+ years progressive project / program management experience in biotech/pharma/diagnostic/device industry along with relevant biologic/pharma/diagnostic/device/drug development background</li><li>Track record of success leading the rollout of quality initiatives in a healthcare environment</li><li>Demonstration of big picture thinking and high-level planning with the ability to navigate comfortably in an ambiguous and fast-paced environment; ability to operate at both big picture and tactical levels.</li><li>Ability to build strong partnerships with internal and external key stakeholders and hold oneself and others accountable for commitments in a productive and collaborative manner</li><li>Business acumen and solid relationship management skills with a focus on cross-functional collaboration and customer service</li><li>Solid understanding of the GMP, GXP and other guidelines relevant to the pharmaceutical industry</li><li>Proactive problem solver able to promote ideas persuasively and build on the ideas of others in a constructive manner</li><li>Command of tools to efficiently communicate complex ideas to a wide array of audiences by providing project summaries to Functional Leadership and updates for the wider company to ensure alignment across disciplines and departments</li><li>Positive attitude and ability to foster the qualities of a high performing team through organizational change management</li></ul>Preferred Qualifications:<ul><li>Experience with biological products or cancer immunotherapies</li><li>Prior experience working in cellular therapy, oncology research</li><li>Expertise in using and / or developing resource management tools</li><li>Prior experience working successfully in a small to mid-size rapidly growing biotech company</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.<h4>&nbsp;</h4>

Senior Program Manager

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Senior Research Associate in the clinical pipeline group to continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.The person in this role will be responsible for evaluation of T cells as part of the product selection process prior to the manufacturing of PACT's adoptive cell therapy product (neoTCR-P1) for clinical patients. This process is performed in a GMP-like laboratory setting and includes characterizing T cell phenotype and functionality using state-of-the-art flow cytometry-based methods and automation. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.Responsibilities:<ul><li>The ideal candidate will perform and thoroughly document ex vivo T cell functional assays according to established procedures</li><li>Demonstrate strong accountability, organizational, and inter-personal skills; will collaborate and work effectively within the team and across multi-functional teams</li><li>Identify areas of the process for improvement and work with the process development team to test and implement improvements</li><li>Analyze flow cytometry data and carefully write reports that will help inform product candidate selection in clinical patients</li><li>Operate advanced liquid handling and robotic laboratory automation</li><li>Become a process expert and mentor/train research associates in performing the workflows</li><li>Assist junior team members with issues that may arise, including any necessary documentation</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s degree with 4+ or Master&rsquo;s with 2+ years of industry experience, preferably in a production environment</li><li>The candidate should be proficient in state-of-the-art techniques for characterizing T cell phenotype and measuring T cell functionality (antigen-specific killing assays, cytokine production, proliferation)</li><li>The candidate should be proficient at cell-based bioassays, ELISA, flow cytometry and primary human T cells and mammalian cell culture</li><li>Must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports</li><li>Demonstrated ability to work well within a team environment is a must</li><li>Experience with automated lab workflows and liquid handlers is a plus</li><li>Experience operating within a formal quality management system. cGMP or ISO 13485 production experience is a plus</li><li>This position will require flexible work schedules (Shift schedules)&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Senior Research Associate

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient's individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are about eradicating cancer, come join our team!&nbsp;We are currently recruiting for a Procurement Manager who will report to the Head of Procurement and continue advancing PACT&rsquo;s cutting-edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.&nbsp;What You Will Do:The Procurement Manager will play a lead role in securing the supplies and services that ensure successful process execution for all areas of the company. The procurement team has responsibility for all purchasing activities for PACT Pharma supporting R&amp;D, G&amp;A, and capital investments. The role will be responsible for generating requests for proposals, negotiating quotes with suppliers, placing orders, and ensuring a stable supply of materials and services throughout the organization. This role is located in South San Francisco.Minimal Qualifications:<ul><li>Oversee daily operations of the Procurement function and serve as a hands-on leader that understands and performs the daily tactical and strategic functions</li><li>Negotiate vendor agreements, contracts, and terms</li><li>Work closely with various functions to ensure proper selection, evaluation, and acquisition of all materials while also mitigating critical situations as they arise with the supplier base</li><li>Track and report key functional metrics to reduce expenses and improve the effectiveness</li><li>Identify, develop and drive operational excellence / continuous improvement</li><li>Be the point of contact for invoice reconciliation of accounts payable</li><li>Actively develop and manage vendor performance using key performance indicators and scorecard development, business reviews, and effective contract change/dispute management process</li><li>Collaborate with business owners to develop accurate scopes of work, including gathering product and service specifications; implement supplier management programs to ensure continuous improvement and monitoring</li><li>Provide training and day-to-day support on procurement systems, policy, and processes for the business unit and/or corporate staff involved in purchasing activities</li><li>Manage vendor relationships and be expected to coordinate work with others, both internally and externally</li><li>Support and execute strategic sourcing policies, practices, and systems&nbsp;</li></ul>Preferred Qualifications: <ul><li>Bachelors Science degree with 6+ years of experience, preferably within&nbsp;biotechnology / pharmaceutical industry procurement</li><li>Working knowledge of cGMPs</li><li>An expert in procurement processes and sourcing of goods and services for the pharmaceutical/biotech industry.</li><li>Demonstrated success in improving organizational performance by developing and promoting talent and providing learning and career growth opportunities for team</li><li>Experience with gene or cell therapy is a plus</li><li>Experience working with Point Purchasing and/or ERP systems is a plus</li><li>Ability to work in a small company and high growth, fast-paced environment&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Procurement Manager

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient's individual tumor and engineering T cells to kill that specific tumor. In principle, this technology can be used to treat any cancer type.&nbsp;If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are about eradicating cancer, come join our team!&nbsp;We are currently recruiting for a Contracts Attorney to join PACT&rsquo;s Legal Department and report to PACT&rsquo;s Associate General Counsel.&nbsp;What You Will Do:This role will support PACT&rsquo;s Research and Development organization as well as other departments within PACT and will include drafting, negotiating, and tracking a high volume of contracts. Essential duties and responsibilities include:<ul><li>Draft, review, and negotiate a wide range of contracts (which may include confidentiality agreements, consulting agreements, materials transfer agreements, license agreements, simple and complex clinical trial agreements, advisory board agreements, consulting agreements, and various vendor services agreements and master agreements)</li><li>Manage PACT&rsquo;s contracts database</li><li>Identify and define operational and legal risks and be able to communicate those risks to appropriate internal decision-makers for discussion and resolution</li><li>Interact with internal clients efficiently and effectively to address legal and business questions</li><li>Interface with research institutions and research vendors to facilitate materials transfer, collaboration, and confidentiality agreements</li><li>Interface with discovery and development vendors to facilitate master services agreements and task orders</li><li>Handle miscellaneous legal tasks on an as-needed basis&nbsp;</li></ul>Qualifications Include:Education:<ul><li>BS/BA degree, preferably in life sciences or a related field</li><li>JD degree required and preferably admitted in California</li></ul>Experience:<ul><li>Preferably requires 2-5 years of experience as an attorney in a law firm or in-house legal environment in the biotechnology or pharmaceuticals industry</li><li>Contract drafting and negotiation experience required</li><li>Contract database use and management required&nbsp;</li></ul>Skills:<ul><li>Demonstrated advanced understanding of business concepts and principles</li><li>Advanced knowledge of legal concepts and principles as they relate to contractual matters</li><li>Experience managing projects with an organization</li><li>Strong organizational and planning skills and meticulous attention to detail</li><li>Ability to effectively prioritize and multi-task</li><li>Excellent verbal and written communication skills to interact in a team-oriented environment required</li><li>Ability in managing vendor relationships, and direct contract resources</li><li>Self-motivated and able to work independently while exercising initiative, flexibility, and good judgment</li><li>Strong desire to improve processes and grow</li><li>Ability to maintain and properly handle highly confidential information</li><li>Computer skills including proficiency in the use of Microsoft Word, Excel, PowerPoint&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;&nbsp;

Contracts Attorney

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Senior Research Associate in the clinical pipeline group to continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.The person in this role will be responsible for evaluation of T cells as part of the product selection process prior to the manufacturing of PACT's adoptive cell therapy product (neoTCR-P1) for clinical patients. This process is performed in a GMP-like laboratory setting and includes characterizing T cell phenotype and functionality using state-of-the-art flow cytometry-based methods and automation. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.Responsibilities:<ul><li>Perform and thoroughly document ex vivo T cell functional assays according to established procedures</li><li>Collaborate and work effectively within the team and across multi-functional teams</li><li>Identify areas of the process for improvement and work with the process development team to test and implement improvements</li><li>Analyze flow cytometry data and carefully write reports that will help inform product candidate selection in clinical patients</li><li>Operate advanced liquid handling and robotic laboratory automation</li><li>Become a process expert and mentor/train research associates in performing the workflows</li><li>Assist junior team members with issues that may arise, including any necessary documentation</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s degree with 5+ or Master&rsquo;s with 2+ years of industry experience, preferably in a production environment</li><li>Proficient in state-of-the-art techniques for characterizing T cell phenotype and measuring T cell functionality (antigen-specific killing assays, cytokine production, proliferation)</li><li>Proficient at cell-based bioassays, ELISA, flow cytometry and primary human T cells and mammalian cell culture</li><li>Must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports</li><li>Demonstrated ability to work well within a team environment is a must</li><li>Demonstrate strong accountability, organizational, and inter-personal skills</li><li>Experience with automated lab workflows and liquid handlers is a plus</li><li>Experience operating within a formal quality management system. cGMP or ISO 13485 production experience is a plus</li><li>This position will require flexible work schedules (Shift schedules)&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently recruiting for a Senior Research Associate in the clinical pipeline group to continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.The person in this role will be responsible for evaluation of T cells as part of the product selection process prior to the manufacturing of PACT's adoptive cell therapy product (neoTCR-P1) for clinical patients. This process is performed in a GMP-like laboratory setting and includes characterizing T cell phenotype and functionality using state-of-the-art flow cytometry-based methods and automation. The ideal candidate should enjoy operating in an exceptionally dynamic and cooperative environment.Responsibilities:<ul><li>The ideal candidate will perform and thoroughly document ex vivo T cell functional assays according to established procedures</li><li>Demonstrate strong accountability, organizational, and inter-personal skills; will collaborate and work effectively within the team and across multi-functional teams</li><li>Identify areas of the process for improvement and work with the process development team to test and implement improvements</li><li>Analyze flow cytometry data and carefully write reports that will help inform product candidate selection in clinical patients</li><li>Operate advanced liquid handling and robotic laboratory automation</li><li>Become a process expert and mentor/train research associates in performing the workflows</li><li>Assist junior team members with issues that may arise, including any necessary documentation</li></ul>Qualifications:<ul><li>Bachelor&rsquo;s degree with 4+ or Master&rsquo;s with 2+ years of industry experience, preferably in a production environment</li><li>The candidate should be proficient in state-of-the-art techniques for characterizing T cell phenotype and measuring T cell functionality (antigen-specific killing assays, cytokine production, proliferation)</li><li>The candidate should be proficient at cell-based bioassays, ELISA, flow cytometry and primary human T cells and mammalian cell culture</li><li>Must have excellent organizational skills and should be able to communicate clearly and concisely, both verbally and in the form of written reports</li><li>Demonstrated ability to work well within a team environment is a must</li><li>Experience with automated lab workflows and liquid handlers is a plus</li><li>Experience operating within a formal quality management system. cGMP or ISO 13485 production experience is a plus</li><li>This position will require flexible work schedules (Shift schedules)&nbsp;</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

PACT Pharma is an exciting, well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient's individual tumor and engineering T cells to kill that specific tumor.If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.We are currently seeking a talented and motivated LIMS System Analyst to join our informatics team.&nbsp;As we&nbsp;continue to grow as a clinical-stage company and build our information science infrastructure, the need for leadership in defining and executing the enterprise data management technology roadmap is critical to the&nbsp;overall&nbsp;development of personalized&nbsp;neoTCR&nbsp;therapies.&nbsp;This individual will be responsible for analysis/evaluation of business and/or system process and functional requirements, development of business cases, client support during system development, and implementation for PACT&rsquo;s lab systems to meet the needs for PACT&rsquo;s needle to needle workflow.Responsibilities:<ul><li>Complete LIMS systems projects by demonstrating expertise in Clinical, LIMS, Manufacturing, and related functional area business processes and understands assigned and cross-functional areas</li><li>Identify and coordinate the analysis of complex client business processes needs into technical specifications</li><li>Perform solution development and the implementation of the final system/service</li><li>Act as a liaison between business clients and technical staff and/or with system integration partners throughout the system development and support life cycle</li><li>Identify opportunities for increasing process efficiency through improved manual and automated process systems</li><li>Work on the development of comprehensive business cases with cost, service, and benefit dimensions of proposed projects that are used at management and executive levels for funding and scope decisions</li><li>Develop cross-initiative integration plans</li><li>Consult on the integration of application systems into the Enterprise Data Management architecture</li><li>Partner with other project managers and implements schedule deadlines as appropriate</li></ul>Qualifications:<ul><li>BS degree in computer science, bioinformatics, engineering, or extensive experience in biotech/pharma/diagnostic/device industry&nbsp;</li><li>5+ years of work experience in a business analyst role for LIMS or scientific data systems</li><li>Experience in evaluating, implementing LIMS and lab automation systems/solutions in a pharma or diagnostics setting.</li><li>Knowledge of regulatory requirements for pharma manufacturing and/or diagnostics.</li><li>Demonstrated experience working with engineering teams to manage system deliverables.</li><li>Experienced with technical decision making, filling the gaps between business requirements and engineering, and suggesting reasonable workarounds when necessary</li><li>Understanding of business needs and perform market research to assess build vs. buy decisions</li><li>Ability to work with vendors and assess product fit for PACT&rsquo;s needs and can manage vendor alliance</li><li>Strong management experience, working with an outsourced team</li><li>Ability to build partnerships and proven ability to influence cross-functional teams without formal authority</li><li>Strong familiarity with SDLC and leading software projects&nbsp;Agile/Scrum experience (previous Waterfall experience is helpful)&nbsp;</li></ul> PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate based on race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;&nbsp;

LIMS System Analyst

PACT Pharma is an exciting, very well-funded clinical-stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. If you desire a stimulating fast-paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team. We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants We are currently recruiting for a Process Engineer who will report to the Associate Director, Manufacturing Sciences and Technology (MSAT), and continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives. This position is responsible for supporting the activities involved in process transfers, compliance, and scalability for PACT&rsquo;s cell and plasmid manufacturing operations. Team members will focus on technology transfers from Process Development into GMP manufacturing facilities as well as driving and developing process automation and scalability solutions to improve process reliability, safety, cost-effectiveness, and compliance. It is expected that the Process Engineer will work closely with other corporate functional areas as well as outside vendors to ensure deliverables are met. Responsibilities:<ul><li>Manage the transfer of manufacturing processes from Process Development or external sites into the PACT GMP facility</li><li>Develop integration solutions for the manufacturing process and data management, including DCS, SCADA, MES, QMS, and LIMS</li><li>Drive and support process automation and scaling initiatives</li><li>Provide process technical support for clinical manufacturing, including deviation investigations, equipment troubleshooting, process failures</li><li>Provide expertise and training of the manufacturing staff on the T cell and/or plasmid manufacturing process and equipment</li><li>Work closely with the Supply chain, Quality Control, Validation, Engineering, Quality Assurance, and Regulatory Affairs functions internally to ensure the facility meets all appropriate standards and T cell/plasmid manufacturing process is performed per GMP requirements</li><li>Coordinate Manufacturing timelines and deliverables through the CMC team, Program Management, and other functions, as appropriate</li><li>Provide, write, and review relevant documentation for T cell/plasmid manufacturing operations and systems</li><li>Perform and support system testing, qualification, and validation</li><li>Position may require some travel</li></ul>Qualifications:<ul><li>BS/MS degree in engineering or life sciences with a strong technical background</li><li>8+ years of experience of related experience</li><li>5+ years of experience in Manufacturing or Development roles with more than 3+ years in a drug product development and manufacturing function at a biotechnology or pharmaceutical company</li><li>Knowledge and experience in leading a technology transfer</li><li>Hands-on experience with GLP, cGMP, and GCP is required</li><li>Experience with aseptic processing and cell therapy manufacturing is preferred</li><li>Experience working in manufacturing/process design is preferred</li><li>Experience in leading meetings, teams, and working directly with outside parties</li><li>Demonstrated management experience including employee development and leadership</li><li>Team player with the ability to influence others and serve as a change agent</li><li>Forward-thinking and creative with high ethical standards</li><li>Well organized and self-directed</li><li>Strong interpersonal skills with an ability to communicate to people at all levels of an organization</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.

Process Engineer

PACT Pharma&nbsp;is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor.&nbsp;In principle, this technology can be used to treat any cancer type.&nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.&nbsp; We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer!&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants.&nbsp;We are currently searching for a&nbsp;Process Development Scientist who will report to the Director of Process Development within our TCR discovery and validation group.The ideal candidate should be creative and interdisciplinary with practical problem-solving skills and hands-on experience in one or more of the following areas: &nbsp;cell biology, flow cytometry, PCR, or next-generation sequencing.This will be a unique opportunity to improve and operationalize PACT&rsquo;s cutting-edge personalized TCR discovery process and see our clinical pipeline through to commercial launch while having a direct impact on patient lives.&nbsp;Responsibilities:&nbsp;<ul><li>Develop, qualify, and implement processes that improve key operational metrics including robustness, reliability, turn-around-time, quality, and cost</li><li>Develop and optimize robust characterization assays using a variety of assay formats and technologies</li><li>Work in collaboration with R&amp;D, bioinformatics, software engineering, automation engineering, QA, and production to develop and deploy high-throughput laboratory automation and software solutions with thorough process controls</li><li>Identify projects, draft proposals, and communicate the feasibility of proposed solutions</li><li>Apply Quality-by-Design principles to define robust, integrated control strategies</li><li>Lead troubleshooting efforts using recognized tools to ensure high production pipeline availability and continuous quality</li></ul>Qualifications:<ul><li>B.S., M.S. or Ph.D. degree in cell or molecular biology, bioengineering, or other relevant biological sciences or engineering disciplines</li><li>8+ (B.S. degree), 5+ (M.S. degree), or 2+ (Ph.D. degree) years industry experience developing assays for use in production workflows</li><li>Ability to propose new projects, design proof of concept experiments, and lead the execution and analysis of the work</li><li>Hands-on experience with workflow development for one or more of the following:&nbsp; cell culture and handling, PCR, flow cytometry, and NGS</li><li>Experience carrying out process characterization to identify and control sources of variability using designed experiments and statistical tools</li><li>Experience in systematic troubleshooting and root cause analysis in a production environment using recognized tools</li><li>Experience developing and characterizing the performance of analytical and functional test methods to ensure quality</li><li>Experience designing and executing validation plans for equipment, processes, and test methods</li><li>Experience developing processes that interface with a LIMS system to manage data capture and analysis</li><li>Highly goal-driven with a demonstrated ability to effectively prioritize and focus on time-sensitive objectives</li><li>Experience operating within a formal quality management system such as CLIA, ISO 13485, or CFR 211</li><li>Ability to communicate clearly and concisely, both verbally and in the form of written reports</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.&nbsp;

Process Development Scientist

Our next virtual Open House is on June 17, 2020. You are invited to our virtual PACT Pharma Open House!&nbsp; &nbsp;This event includes:&nbsp;&nbsp;<ul><li>An introduction to our open positions from our recruiters, how to apply, and what PACT Pharma looks for</li><li>You'll hear from some of our Scientists &amp; RA's about what it's like to work here, info about our technology, and what they love about PACT Pharma</li><li>Our Scientist will bring you on a journey of our science and process.</li><li>We will also answer your questions!</li></ul>Please click on the apply button to submit your CV for your RSVP.&nbsp; If you have any questions you want answered, reply to the automated email and we will make sure to get to them during the event. &nbsp;If you forget, don't worry, we will have a way for you to ask during the Open House with any of our remaining time.&nbsp; &nbsp; We will be emailing you the zoom link and reminders as the date gets closer.&nbsp;We look forward to seeing you there!PACT Talent Acquisition&nbsp;Team

Career Open House (June 17, 2021)

PACT Pharma is an exciting, well-funded clinical stage company developing personalized adoptive T cell therapies for the eradication of solid tumors. Our private designer T cells are created by analyzing a patient&rsquo;s individual tumor and engineering T cells to kill that specific tumor. &nbsp;If you desire a stimulating fast paced environment, working with intelligent people who are making an impact in cancer, you will want to join the PACT Pharma team.  We are a rapidly expanding, innovative, and collaborative workforce working towards one main goal, eradicating cancer! &nbsp;&nbsp;We are in the San Francisco bay area, the heart of the world&rsquo;s premier biotechnology research hub. PACT Pharma offers a competitive compensation and benefits package, including participation in the aggressive growth of the company in the form of stock option grants. &nbsp;&nbsp;We are currently recruiting for a Scientist I, Gene Editing who will report to the Associate Director of Laboratory&nbsp;Operations and&nbsp;continue advancing PACT&rsquo;s cutting edge engineered cell product. This will be a unique opportunity to see your ideas rapidly translate into the clinic and impact patient lives.  The individual will be responsible for the execution of high-throughput gene editing platforms and methods which will be utilized for next-generation T cell therapies. Molecular construct design, validation, data analysis, and regulatory report generation will be key components of your work.&nbsp;&nbsp;The position involves a considerable amount of bench work in a GMP-like environment executing protocols&nbsp;and authoring SOPs to&nbsp;&nbsp; support our clinical&nbsp;operations. The ideal candidate should have keen attention to details, be highly organized and should enjoy operating in an exceptionally dynamic and collaborative environment. &nbsp; Responsibilities: &nbsp;<ul><li>Work with the HTP protein production operations team to streamline the workflow and optimize the pipeline to improve efficiency in the operations process</li><li>Lead 2-3 highly competent RA&rsquo;s and assign work on a daily and weekly basis</li><li>Serve as the technical lead on the&nbsp;gene editing&nbsp;production operations pipeline and provide scientific guidance to the junior staff</li><li>Implement solutions to operations pipeline bottlenecks</li><li>Resolve quality issues with production pipeline as and when they arise</li><li>Coordinate and collaborate with other scientists in the team to reduce cycle-time and improve efficiency</li><li> Track and prioritize activities within the&nbsp;gene editing protein production sub-group</li></ul> Qualifications: &nbsp;<ul><li>Masters with 5+ years of experience in Protein Biochemistry, Molecular&nbsp;Biology&nbsp;or related disciplines.&nbsp;</li><li>PhD with 2+ years of experience in Protein Biochemistry, Molecular Biology or related disciplines preferred</li><li>Experience with HTP molecular cloning,&nbsp;molecular construct design,&nbsp;protein expression &amp; analysis is required</li><li>Prior experience with mammalian cell culture and with recombinant protein expression is essential</li><li>Acute attention to details, well-organized, diligent with documentation</li><li>Highly goal-driven with the ability to handle delicate experiments in a timely manner</li><li>Able to operate in a collaborative environment and communicate clearly and concisely, both verbally and in the form of written reports</li><li> Experience working with automated platforms</li></ul>PACT Pharma is proud to be an equal opportunity employer and strives to build a diverse and inclusive team. We do not discriminate on the basis of race, color, national origin, religion, gender, sexual orientation, age, marital status, veteran status, or disability status.  &nbsp;&nbsp;&nbsp;

Scientist, Gene Editing Clinical Pipeline

“I joined PACT to work with our impressive management team and innovative technologies to improve cancer therapies. It is the people that make this company exceptional and the mission to cure cancer that motivates me.”

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Rebecca.jpg

Director

"I joined PACT because of the science and the people!  PACT is a special place where people work hard because they are passionate about the science, committed to patients, value teamwork and push the boundaries to never accept the status quo. For those who thrive in a fast paced and innovative environment, PACT provides a rewarding opportunity to tackle challenging projects in a collaborative way."

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Susan.png

Vice President

“I joined PACT Pharma because I was energized by the people and the purpose of the organization and have been continuously impressed by the drive and ambition of the whole team to overcome any challenges. Being encouraged to be authentic with one another, and in all of our work, has really built a strong, unified team. This has been a unique and very rewarding experience for me.”

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Brian_Birdi.jpg

Associate Director

“When I first interviewed at PACT, I remember being impressed by the collaborative and open nature of research within the company. It left quite the impression with me and ultimately guided me towards choosing a career at PACT. Since joining, I am continually grateful for the level of openness and collaboration between teams and departments that is crucial for pioneering scientific work."


Accelerating CurativeT Cell Therapiesfor Cancer

Tailored for Each and Every Person

PACT Pharma Announces Planned Retirement of CEO Alex Franzusoff, Veteran Biotech Executive Scott Garland Named as...

Who We Are

Mission & Vision

Our
Platform

Our
Programs

PACT Voices

Director

Technical Operations

Vice President

Program Management

Associate Director

Automation

Scientist

Tumor Immunology

Join Us

Quality Assurance Director - Upstream Operations

Scientist - Gene Editing/Molecular Biology

Accelerating CurativeT Cell Therapiesfor Cancer

Tailored for Each and Every Person

PACT Pharma Announces Planned Retirement of CEO Alex Franzusoff, Veteran Biotech Executive Scott Garland Named as...

Who We Are

Mission & Vision

OurPlatform

OurPrograms

PACT Voices

Director

Technical Operations

Vice President

Program Management

Associate Director

Automation

Scientist

Tumor Immunology

Join Us

Quality Assurance Director - Upstream Operations

Scientist - Gene Editing/Molecular Biology

Our
Platform

Our
Programs